Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The 4-Year Experience with Implementation and Routine Use of Pathogen Inactivation in a Brazilian Hospital

Version 1 : Received: 25 October 2021 / Approved: 27 October 2021 / Online: 27 October 2021 (12:27:33 CEST)

A peer-reviewed article of this Preprint also exists.

Fachini, R.M.; Fontão-Wendel, R.; Achkar, R.; Scuracchio, P.; Brito, M.; Amaral, M.; Wendel, S. The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital. Pathogens 2021, 10, 1499. Fachini, R.M.; Fontão-Wendel, R.; Achkar, R.; Scuracchio, P.; Brito, M.; Amaral, M.; Wendel, S. The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital. Pathogens 2021, 10, 1499.

Journal reference: Pathogens 2021, 10, 1499
DOI: 10.3390/pathogens10111499

Abstract

(1) Background: We reviewed the logistics of the implementation of pathogen inactivation (PI) using the INTERCEPT Blood System™ for platelets and the experience with routine use and clinical outcomes in the patient population at the Sírio-Libanês Hospital of São Paulo, Brazil. (2) Methods: Platelet concentrate (PC), including pathogen reduced (PR-PC) production, inventory management, discard rates, blood utilization, and clinical outcomes were analyzed over the 40 months before and after PI implementation. Age distribution and wastage rates were compared over the 10 months before and after approval for PR-PC to be stored for up to 7 days. (3) Results: A 100% PR-PC inventory was achieved by increasing double apheresis collections and production of double doses using pools of two single apheresis units. Discard rates decreased from 6% to 3% after PI implementation and further decreased to 1.2% after 7-day storage extension for PR-PCs. The blood utilization remained stable, with no increase in component utilization. A significant decrease in adverse transfusion events was observed after the PI implementation. (4) Conclusion: Our experience demonstrates the feasibility for Brazilian blood centers to achieve a 100% PR-PC inventory. All patients at our hospital received PR-PC and showed no increase in blood component utilization and decreased rates of adverse transfusion reactions.

Keywords

pathogen reduction; blood safety; platelet transfusion; INTERCEPT; plasma

Subject

MEDICINE & PHARMACOLOGY, Other

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.