Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Comparative Immunogenicity Evaluation of Two Commonly Used Infectious Bursal Disease Vaccines in Broiler Chickens in Ethiopia

Version 1 : Received: 18 October 2021 / Approved: 19 October 2021 / Online: 19 October 2021 (08:51:54 CEST)

How to cite: Legese, L.; Wakjira, B.; Teshome, T.; Woldemichael, D.N.; Waktole, H.; Regassa, F.; Tufa, T.B. Comparative Immunogenicity Evaluation of Two Commonly Used Infectious Bursal Disease Vaccines in Broiler Chickens in Ethiopia. Preprints 2021, 2021100263 (doi: 10.20944/preprints202110.0263.v1). Legese, L.; Wakjira, B.; Teshome, T.; Woldemichael, D.N.; Waktole, H.; Regassa, F.; Tufa, T.B. Comparative Immunogenicity Evaluation of Two Commonly Used Infectious Bursal Disease Vaccines in Broiler Chickens in Ethiopia. Preprints 2021, 2021100263 (doi: 10.20944/preprints202110.0263.v1).

Abstract

Infectious bursal disease (IBD) is one of the most endemic diseases of commercial poultry in Ethiopia. Vaccination has been practiced as the major means of IBD prevention and control. A study was conducted to determine and compare the immunogenicity of two commercially available IBD vaccines in broiler chicken with maternally derived antibody (MDA). Day-old chickens of 270 were randomly assigned to three groups, group 1 vaccinated with brand 1 vaccine at 7th and 19th days and group 2 with brand 2 vaccine at 15th and 22nd days while group 3 were kept as control. Six chickens were also randomly selected and bled on day 1 for differential leukocyte count (DLC) and determination of MDA. Representative chickens from each group were bled at 24th and 42nd days of age for antibody titration using the indirect ELISA test. DLC scores were determined in the 1st and 24th days. The result revealed highly significant differences (P = 0.001) between group 1 and group 2 in DLC at 24th days of age. Antibody titers against IBD were differed significantly (P = 0.02) at 24th and 42nd days of age in broilers vaccinated with brand 1 and brand 2 vaccines. It is concluded that although both brands of vaccine induce an adequate immunological response at the end of the experiment, brand 1 vaccine has shown significantly high antibody titers against the IBDV and DLC than brand 2.

Keywords

Antibody titer; Broiler chicken; IBD vaccines; Immunogenicity evaluation

Subject

MEDICINE & PHARMACOLOGY, Veterinary Medicine

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