Preprint Technical Note Version 1 Preserved in Portico This version is not peer-reviewed

CiLiQuant: Quantification of RNA Junction Reads Based on Their Circular or Linear Transcript Origin

Version 1 : Received: 9 September 2021 / Approved: 10 September 2021 / Online: 10 September 2021 (11:17:04 CEST)

How to cite: Morlion, A.; Hulstaert, E.; Anckaert, J.; Everaert, C.; Vandesompele, J.; Mestdagh, P. CiLiQuant: Quantification of RNA Junction Reads Based on Their Circular or Linear Transcript Origin. Preprints 2021, 2021090183 (doi: 10.20944/preprints202109.0183.v1). Morlion, A.; Hulstaert, E.; Anckaert, J.; Everaert, C.; Vandesompele, J.; Mestdagh, P. CiLiQuant: Quantification of RNA Junction Reads Based on Their Circular or Linear Transcript Origin. Preprints 2021, 2021090183 (doi: 10.20944/preprints202109.0183.v1).

Abstract

Distinguishing circular RNA (circRNA) reads from reads derived from the linear host transcript is a challenging task because of sequence overlap. We developed a computational approach, CiLiQuant, that determines the relative circular and linear abundance of transcripts and gene loci using backsplice and forward splice junction reads generated by existing mapping and circRNA discovery tools.

Keywords

bioinformatics; circRNA

Subject

LIFE SCIENCES, Molecular Biology

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