Wendt, R.; Lingitz, M.; Laggner, M.; Mildner, M.; Traxler, D.; Graf, A.; Krotka, P.; Moser, B.; Hoetzenecker, K.; Kalbitz, S.; Luebbert, C.; Beige, J.; Ankersmit, H.J. Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome in Patients with COVID-19. Preprints2021, 2021080440. https://doi.org/10.20944/preprints202108.0440.v1
Wendt, R., Lingitz, M., Laggner, M., Mildner, M., Traxler, D., Graf, A., Krotka, P., Moser, B., Hoetzenecker, K., Kalbitz, S., Luebbert, C., Beige, J., & Ankersmit, H.J. (2021). Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome in Patients with COVID-19. Preprints. https://doi.org/10.20944/preprints202108.0440.v1
Wendt, R., Joachim Beige and Hendrik Jan Ankersmit. 2021 "Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome in Patients with COVID-19" Preprints. https://doi.org/10.20944/preprints202108.0440.v1
Although, severe acute respiratory syndrome coronavirus – 2 (SARS-CoV 2) represents one of the biggest challenges in the world today, the exact immunopathogenic mechanism that leads to severe or critical Coronavirus Disease 2019 (COVID-19) has remained incompletely understood. Several studies have indicated that high systemic plasma levels of inflammatory cytokines result in the so-called “cytokine storm”, with subsequent development of microthrombosis, disseminated intravascular coagulation, and multiorgan-failure. Therefore, we reasoned that elevated inflammatory cytokine might act as prognostic factors. Here, we analyzed 245 serum samples of patients with COVID-19, collected at hospital admission. We assessed the levels of heat shock protein 27 (HSP27), soluble suppressor of tumorigenicity- 2 (sST2), caspase cleaved cytokeratin 18 (cCK18), 20S proteasome, and tumor necrosis factor receptor 1 (TNFR-1) and explored their associations with overall-, 30-, 60-, 90-day- and in-hospital mortality. Moreover, we investigated their association with the risk of ventilation. We demonstrated that increased serum sST2 was uni- and multivariably associated with all endpoints. However, we also identified 20S proteasome as independent prognostic factor for in-hospital mortality. Furthermore, elevated HSP27, sST2, and 20S proteasome levels at hospital admission were univariably associated with higher risk of invasive ventilation. These findings could help to identify high-risk patients early in the course of COVID-19.
COVID-19; HSP27; sST2; ARDS; biomarker
Biology and Life Sciences, Immunology and Microbiology
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