CO-St (COVID 19- study): impact of the management of men versus women in the treatment of Covid 19. A Multi-Centric Observational study

Tiziana Ciarambino; filomena pietrantonio; Sara Rotunno; Alessandra Fiorentini; Rosalba Cipriani; Giuseppe Campagna; Giuseppe Straface; Eleonora Pistella; mauro giordano; Francesco Rosiello; Orazio Valerio Giannico; federica lorenzi

doi:10.20944/preprints202108.0119.v1

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preprints.org > medicine and pharmacology > epidemiology and infectious diseases > doi: 10.20944/preprints202108.0119.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

CO-St (COVID 19- study): impact of the management of men versus women in the treatment of Covid 19. A Multi-Centric Observational study

Tiziana Ciarambino

filomena pietrantonio

Sara Rotunno

Alessandra Fiorentini

^* ,

Orazio Valerio Giannico

federica lorenzi

Version 1 : Received: 3 August 2021 / Approved: 4 August 2021 / Online: 4 August 2021 (15:30:46 CEST)

How to cite: Ciarambino, T.; pietrantonio, F.; Rotunno, S.; Fiorentini, A.; Cipriani, R.; Campagna, G.; Straface, G.; Pistella, E.; giordano, M.; Rosiello, F.; Giannico, O.V.; lorenzi, F. CO-St (COVID 19- study): impact of the management of men versus women in the treatment of Covid 19. A Multi-Centric Observational study. Preprints 2021, 2021080119. https://doi.org/10.20944/preprints202108.0119.v1 Ciarambino, T.; pietrantonio, F.; Rotunno, S.; Fiorentini, A.; Cipriani, R.; Campagna, G.; Straface, G.; Pistella, E.; giordano, M.; Rosiello, F.; Giannico, O.V.; lorenzi, F. CO-St (COVID 19- study): impact of the management of men versus women in the treatment of Covid 19. A Multi-Centric Observational study. Preprints 2021, 2021080119. https://doi.org/10.20944/preprints202108.0119.v1

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MDPI and ACS Style

Ciarambino, T.; pietrantonio, F.; Rotunno, S.; Fiorentini, A.; Cipriani, R.; Campagna, G.; Straface, G.; Pistella, E.; giordano, M.; Rosiello, F.; Giannico, O.V.; lorenzi, F. CO-St (COVID 19- study): impact of the management of men versus women in the treatment of Covid 19. A Multi-Centric Observational study. Preprints 2021, 2021080119. https://doi.org/10.20944/preprints202108.0119.v1

APA Style

Ciarambino, T., pietrantonio, F., Rotunno, S., Fiorentini, A., Cipriani, R., Campagna, G., Straface, G., Pistella, E., giordano, M., Rosiello, F., Giannico, O.V., & lorenzi, F. (2021). CO-St (COVID 19- study): impact of the management of men versus women in the treatment of Covid 19. A Multi-Centric Observational study. Preprints. https://doi.org/10.20944/preprints202108.0119.v1

Chicago/Turabian Style

Ciarambino, T., Orazio Valerio Giannico and federica lorenzi. 2021 "CO-St (COVID 19- study): impact of the management of men versus women in the treatment of Covid 19. A Multi-Centric Observational study" Preprints. https://doi.org/10.20944/preprints202108.0119.v1

Abstract

Background: from December 2019 and the spreading of syndemics, a lot of medical centers reg-istered data about their patients. In Italy, the most relevant quantity of patients was hospitalized in internal medicine wards. Methods: In this observational, retrospective cross-sectional study, all data of the COVID-19 patients, admitted Latio hospitals, from March 01 to December 31, 2020, were collected and their Epidemiological data, demographics, signs and symptoms on admission, comorbidities, laboratory findings, chest radiography and CT findings, treatment received and mortality rate were analyzed by gender to find any differences of gravity of disease. Clinician details were registered on database (one for every hospital). Cost analysis was performed by length of stay and antiviral drugs use, using point of view of Italian Healthcare System. Results: 2256 patients with mean age of 71.01 ± 28.02 years were included. For men, frequency of hyper-tension, COPD, use of oxygen therapy, Tocilizumab were significantly higher and epidemiolog-ical link was related to rehabilitation ward and community. The gender difference about hospi-talization was one day more for man. No strong significant difference by gender in the death rate was observed. Considering antiviral drugs and hospitalization, a man costs €1000 more than woman. Conclusions: In male patients, hypertension and COPD were observed more frequently and the epidemiological link was related to rehabilitation ward and community. In female sub-jects, the epidemiological link was related to Hospital and we observed significantly higher atypical chest-X ray. Tocilizumab, oxygen therapy and antiviral drugs were prescribed more in male subjects. No differences by gender we report in other treatments and outcomes. Future studies should be analyzed to get a more comprehensive understanding of COVID-19 by gender.

Keywords

SARS-CoV-2; COVID-19; gender role; sex differences

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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