Serologic Response to mRNA COVID-19 Vaccination in Lymphoma Patients

How to cite: Jurgens, E.M.; Ketas, T.J.; Zhao, Z.; Satlin, M.J.; Small, C.B.; Sukhu, A.; Francomano, E.; Klasse, P.; Garcia, A.; Nguyenduy, E.; Bhavsar, E.; Formenti, S.; Furman, R.; Moore, J.P.; Leonard, J.P.; Martin, P. Serologic Response to mRNA COVID-19 Vaccination in Lymphoma Patients. Preprints 2021, 2021070639 Jurgens, E.M.; Ketas, T.J.; Zhao, Z.; Satlin, M.J.; Small, C.B.; Sukhu, A.; Francomano, E.; Klasse, P.; Garcia, A.; Nguyenduy, E.; Bhavsar, E.; Formenti, S.; Furman, R.; Moore, J.P.; Leonard, J.P.; Martin, P. Serologic Response to mRNA COVID-19 Vaccination in Lymphoma Patients. Preprints 2021, 2021070639

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MDPI and ACS Style

Jurgens, E.M.; Ketas, T.J.; Zhao, Z.; Satlin, M.J.; Small, C.B.; Sukhu, A.; Francomano, E.; Klasse, P.; Garcia, A.; Nguyenduy, E.; Bhavsar, E.; Formenti, S.; Furman, R.; Moore, J.P.; Leonard, J.P.; Martin, P. Serologic Response to mRNA COVID-19 Vaccination in Lymphoma Patients. Preprints 2021, 2021070639

APA Style

Jurgens, E.M., Ketas, T.J., Zhao, Z., Satlin, M.J., Small, C.B., Sukhu, A., Francomano, E., Klasse, P., Garcia, A., Nguyenduy, E., Bhavsar, E., Formenti, S., Furman, R., Moore, J.P., Leonard, J.P., & Martin, P. (2021). Serologic Response to mRNA COVID-19 Vaccination in Lymphoma Patients. Preprints. https://doi.org/

Chicago/Turabian Style

Jurgens, E.M., John P. Leonard and Peter Martin. 2021 "Serologic Response to mRNA COVID-19 Vaccination in Lymphoma Patients" Preprints. https://doi.org/

Abstract

Currently available COVID-19 mRNA vaccines have demonstrated high efficacy in clinical trials.1-3 However, cancer patients, including those with hematological malignancies, were largely excluded from these trials. In this prospective, observational study we measured anti-S protein IgG titers as well as avidity in lymphoma patients (n=67) vaccinated with a COVID-19 mRNA vaccine. Serological response rates in lymphoma patients who were treatment naïve (100% in CLL, 88.9% in other, non-CLL non-Hodgkin lymphoma patients), or who were last treated more than 24 months prior to vaccination (100% in CLL, 90% in other-NHL), were similar to healthy controls (100%). Patients on active therapy, however, had a diminished response rate (40% in CLL, 21.0% in other-NHL). No patient who received anti-CD20 monoclonal antibodies (mAb) within six months of vaccination responded. Thus, the utility of testing anti-S titers should be explored in patients on active therapy or with recent anti-CD20 mAb exposure, to assess their response to vaccination. We also propose studying passive protection with S-protein mAbs as an alternative prophylactic strategy for patients who respond poorly to vaccination.

Keywords

COVID-19; lymphoma; BNT162b2; mRNA-1273

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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