Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers in Meningioma

Version 1 : Received: 22 July 2021 / Approved: 23 July 2021 / Online: 23 July 2021 (22:06:24 CEST)

A peer-reviewed article of this Preprint also exists.

Roesler, R.; Souza, B.K.; Isolan, G.R. Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers and Therapeutic Targets in Meningioma. Int. J. Mol. Sci. 2021, 22, 11352. Roesler, R.; Souza, B.K.; Isolan, G.R. Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers and Therapeutic Targets in Meningioma. Int. J. Mol. Sci. 2021, 22, 11352.

Journal reference: Int. J. Mol. Sci. 2021, 22, 11352
DOI: 10.3390/ijms222111352

Abstract

Meningioma (MGM) is the most common type of intracranial tumor in adults. The validation of novel prognostic biomarkers to better inform tumor stratification and clinical prognosis is urgently needed. Many molecular and cellular alterations have been described in MGM tumors over the past few years, providing a rational basis for the identification of biomarkers and therapeutic targets. The role of receptor tyrosine kinase (RTKs), including those of the ErbB family of receptors, as oncogenes has been well established in several cancer types. Here, we review histological, molecular, and clinical evidence suggesting that RTKs, including the epidermal growth factor receptor (EGFR, ErbB 1), as well as other members of the ErbB family, may be useful as biomarkers in MGM.

Keywords

epidermal growth factor receptor; ErbB; biomarker; meningioma; intracranial tumor

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