Working Paper Article Version 1 This version is not peer-reviewed

Independently Dose-Responsive Association between Fetuin-a and Lean Nonalcoholic Fatty Liver Disease

Version 1 : Received: 3 July 2021 / Approved: 5 July 2021 / Online: 5 July 2021 (12:32:33 CEST)

A peer-reviewed article of this Preprint also exists.

Lu, C.-W.; Lee, Y.-C.; Chiang, C.-H.; Chang, H.-H.; Yang, W.-S.; Huang, K.-C. Independent Dose–Response Associations between Fetuin-A and Lean Nonalcoholic Fatty Liver Disease. Nutrients 2021, 13, 2928. Lu, C.-W.; Lee, Y.-C.; Chiang, C.-H.; Chang, H.-H.; Yang, W.-S.; Huang, K.-C. Independent Dose–Response Associations between Fetuin-A and Lean Nonalcoholic Fatty Liver Disease. Nutrients 2021, 13, 2928.

Journal reference: Nutrients 2021, 13, 2928
DOI: 10.3390/nu13092928

Abstract

Patients with lean NAFLD make up an increasing subset of liver diseases. The association between lean NAFLD and feutin-A, which serves as a hepatokine and adipokine, has never been examined. Our study aimed to explore the association of serum fetuin-A among lean and nonlean patients. The study comprised 606 adults from the community, stratified into lean or nonlean (BMI </≥ 24 kg/m2) and NAFLD or non-NAFLD (scoring of ultrasonographic fatty liver indicator, US-FLI ≥ 2/<2). Multivariate logistic regression analyses were performed to estimate the odds ratio of having NAFLD among the tertiles of fetuin-A after adjustment. The least square means were computed by general linear models to estimate marginal means of the serum fetuin-A concentrations in relation to the NAFLD groups. The OR of having NAFLD for the highest versus the lowest tertile of fetuin-A was 2.62 (95% CI: 1.72-3.98; P for trend<0.001). Stratifying by BMI, the OR of having lean NAFLD for the highest versus the lowest tertile of fetuin-A was 2.09 (95% CI: 1.09-3.98; P for trend 0.026), while nonlean NAFLD had no significant association with the fetuin-A gradient after adjustments. Fetuin-A was positively associated with lean NAFLD after adjusting for central obesity and insulin resistance.

Keywords

central obesity; fetuin-A; lean NAFLD; insulin resistance

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