Working Paper Brief Report Version 1 This version is not peer-reviewed

Preliminary Evaluation of Cannabidiol Use in an Asian Elephant: Brief Report

Version 1 : Received: 11 June 2021 / Approved: 16 June 2021 / Online: 16 June 2021 (11:59:03 CEST)

How to cite: Ortiz, F.; Castillo, M.; Hernández, Q.; Flores, C. Preliminary Evaluation of Cannabidiol Use in an Asian Elephant: Brief Report. Preprints 2021, 2021060442 Ortiz, F.; Castillo, M.; Hernández, Q.; Flores, C. Preliminary Evaluation of Cannabidiol Use in an Asian Elephant: Brief Report. Preprints 2021, 2021060442

Abstract

The Asian elephant (Elephas maximus) is one of the largest herbivore mammals in the world. A portion of the total elephant population is under human care, where health problems such as skin lesions and decreased appetite are reported. The objective of this study was to apply the therapeutic properties of cannabidiol (CBD) to aid treatment of palmar abscesses and a suboptimal food intake in a female Asian elephant in Mexico. A CBD-isolate compounded medication was administered orally at a dose of 0.05 mg/kg/day. CBD administration showed positive effects such as reduction in abscess size, decreased food selectivity, increased food intake, weight gain and increased mobility. More research in elephants is needed to understand their cannabinoid pharmacodynamics and pharmacokinetics and proposing a dosage range and therapeutic applications for this species.

Keywords

Asian elephant; Elephas maximus; cannabidiol; cannabis; CBD; endocannabinoid system

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