Mardaneh, J.; Nasirzadeh, A.; Bazeli, J.; Hajavi, J.; Zahedi, M.; Abounoori, M.; Razavi, A.; Maddah, M.M.; Mortazavi, P.; Moradi, M.; Salehi, F.; Heidarzadeh, S.; Jafarzadeh Maivan, M.H.; Shoeibi, A.; Alizadehsani, R.; Islam, S.M.S. Inhibiting NF-κB During Cytokine Storm in COVID-19: Potential Role of Natural Products as a Promising Therapeutic Approach. Preprints2021, 2021060130. https://doi.org/10.20944/preprints202106.0130.v1
APA Style
Mardaneh, J., Nasirzadeh, A., Bazeli, J., Hajavi, J., Zahedi, M., Abounoori, M., Razavi, A., Maddah, M.M., Mortazavi, P., Moradi, M., Salehi, F., Heidarzadeh, S., Jafarzadeh Maivan, M.H., Shoeibi, A., Alizadehsani, R., & Islam, S.M.S. (2021). Inhibiting NF-κB During Cytokine Storm in COVID-19: Potential Role of Natural Products as a Promising Therapeutic Approach. Preprints. https://doi.org/10.20944/preprints202106.0130.v1
Chicago/Turabian Style
Mardaneh, J., Roohallah Alizadehsani and Sheikh Mohammed Shariful Islam. 2021 "Inhibiting NF-κB During Cytokine Storm in COVID-19: Potential Role of Natural Products as a Promising Therapeutic Approach" Preprints. https://doi.org/10.20944/preprints202106.0130.v1
Abstract
Many inflammatory mechanisms are involved in the pathophysiology of COVID-19 infection. COVID-19 inhibits IFN antiviral responses, so we should expect an out-of-control viral replication. “Cytokine storms” occur due to the over-production of pro-inflammatory cytokines after an influx of neutrophils and monocytes/macrophages and may be responsible for the immunopathology of the lung involvement. Several cascades have been reported in the activation process of NF-κB. In this paper, to find new therapeutic options for COVID-19 infection, we reviewed some natural products that could potentially inhibit the NF-κB pathway. We found that sevoflurane, quercetin, resveratrol, curcumin, KIOM-C, bergenin, garcinia kola, shenfu, piperlongumine, wogonin, oroxylin, plantamajoside, naringin, ginseng, kaempferol, allium sativum L, illicium henryi, isoliquiritigenin, lianhua qingwen, magnoflorine, and ma Huang Tang might be effective in inhibiting the NF-KB pathway. These natural products could be helpful in the control of COVID-19 infections. However, larger clinical trials are needed to ascertain the efficacy of these products fully.
Keywords
COVID-19; Pandemic; Natural Products; NF-KB
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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