Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Inhibiting NF-κB During Cytokine Storm in COVID-19: Potential Role of Natural Products as a Promising Therapeutic Approach

Version 1 : Received: 2 June 2021 / Approved: 4 June 2021 / Online: 4 June 2021 (10:00:12 CEST)

How to cite: Mardaneh, J.; Nasirzadeh, A.; Bazeli, J.; Hajavi, J.; Zahedi, M.; Abounoori, M.; Razavi, A.; Maddah, M.M.; Mortazavi, P.; Moradi, M.; Salehi, F.; Heidarzadeh, S.; Jafarzadeh Maivan, M.H.; Shoeibi, A.; Alizadehsani, R.; Islam, S.M.S. Inhibiting NF-κB During Cytokine Storm in COVID-19: Potential Role of Natural Products as a Promising Therapeutic Approach. Preprints 2021, 2021060130 (doi: 10.20944/preprints202106.0130.v1). Mardaneh, J.; Nasirzadeh, A.; Bazeli, J.; Hajavi, J.; Zahedi, M.; Abounoori, M.; Razavi, A.; Maddah, M.M.; Mortazavi, P.; Moradi, M.; Salehi, F.; Heidarzadeh, S.; Jafarzadeh Maivan, M.H.; Shoeibi, A.; Alizadehsani, R.; Islam, S.M.S. Inhibiting NF-κB During Cytokine Storm in COVID-19: Potential Role of Natural Products as a Promising Therapeutic Approach. Preprints 2021, 2021060130 (doi: 10.20944/preprints202106.0130.v1).

Abstract

Many inflammatory mechanisms are involved in the pathophysiology of COVID-19 infection. COVID-19 inhibits IFN antiviral responses, so we should expect an out-of-control viral replication. “Cytokine storms” occur due to the over-production of pro-inflammatory cytokines after an influx of neutrophils and monocytes/macrophages and may be responsible for the immunopathology of the lung involvement. Several cascades have been reported in the activation process of NF-κB. In this paper, to find new therapeutic options for COVID-19 infection, we reviewed some natural products that could potentially inhibit the NF-κB pathway. We found that sevoflurane, quercetin, resveratrol, curcumin, KIOM-C, bergenin, garcinia kola, shenfu, piperlongumine, wogonin, oroxylin, plantamajoside, naringin, ginseng, kaempferol, allium sativum L, illicium henryi, isoliquiritigenin, lianhua qingwen, magnoflorine, and ma Huang Tang might be effective in inhibiting the NF-KB pathway. These natural products could be helpful in the control of COVID-19 infections. However, larger clinical trials are needed to ascertain the efficacy of these products fully.

Subject Areas

COVID-19; Pandemic; Natural Products; NF-KB

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