Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Potential Drugs for COVID -19 Treatment Management With Their Contraindications and Drug- Drug Interaction

Version 1 : Received: 26 May 2021 / Approved: 28 May 2021 / Online: 28 May 2021 (10:18:45 CEST)

How to cite: Talukdar, D.; Jain, V.; Balaramnavar, V.; Srivastava, S.P.; Sivanandy, P.; Gupta, M.M. Potential Drugs for COVID -19 Treatment Management With Their Contraindications and Drug- Drug Interaction. Preprints 2021, 2021050690 (doi: 10.20944/preprints202105.0690.v1). Talukdar, D.; Jain, V.; Balaramnavar, V.; Srivastava, S.P.; Sivanandy, P.; Gupta, M.M. Potential Drugs for COVID -19 Treatment Management With Their Contraindications and Drug- Drug Interaction. Preprints 2021, 2021050690 (doi: 10.20944/preprints202105.0690.v1).

Abstract

Novel Coronavirus (2019-nCOV) causes inflammatory response with worsening symptoms. Classification of potential anti-viral and anti-inflammatory drugs in managing the symptoms of the COVID-19 and reducing morbidity is important. The objective of this study is to identify a group of drugs, best suited for COVID-19 treatment based on recent developments in clinical trials, FDA drug evaluation, directions and developments and from drug therapies globally. Online literature search was done on Medline, PubMed and google scholar databases for studies on various treatments and drug therapies for COVID-19 and relevant studies were identified and the identified drugs are described in detail as per their Pharmacological, pharmaceutical properties of the drugs, mechanism of action, current COVID-19 drug therapy, contraindications and drug-drug interactions Certain drugs can inhibit action against viral infection and protect lungs from severe inflammatory response. This article summarizes several drugs like Hydroxychloroquine, Chloroquine, Remdesivir, Favipiravir, Lopinavir, Ritonavir, Dexamethasone, Ivermectin, Baricitinib, Casirivimab / imdevimab, Bamlanivimab along with auxiliary treatment like convalescent plasma transfusion. Remdesivir is first drug approved by FDA. Hydroxychloroquine, dexamethasone and remdesivir are showing results against COVID-19 but it is important to test the efficacy and safety of such drugs though some drugs have shown remarkable results.

Keywords

COVID-19; SARS-CoV-2; Chloroquine; Hydroxychloroquine; Remdesivir; Favipiravir; Dexamethasone; Remdesivir

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