Preserved in Portico This version is not peer-reviewed
Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems
: Received: 26 May 2021 / Approved: 27 May 2021 / Online: 27 May 2021 (15:06:56 CEST)
: Received: 7 June 2021 / Approved: 7 June 2021 / Online: 7 June 2021 (14:45:53 CEST)
A peer-reviewed article of this Preprint also exists.
Journal reference: Applied Sciences 2021, 11, 5839
Current, application-driven trends towards larger-scale integration (LSI) of microfluidic systems for comprehensive assay automation and multiplexing pose significant technological and economical challenges to developers. By virtue of their intrinsic capability for powerful sample preparation, centrifugal systems have attracted significant interest in academia and business since the early 1990s. This review models common, rotationally controlled valving schemes at the heart of such “Lab-on-a-Disc” (LoaD) platforms to predict critical spin rates and reliability of flow control mainly based on geometries, location and liquid volumes to be processed, and their experimental tolerances. In absence of larger-scale manufacturing facilities during product development, the method presented here facilitates the provision of efficient simulation tools for virtual prototyping and characterization to greatly expedite design optimization according to key performance metrics. This virtual in silico approach thus significantly accelerates, de-risks and lowers costs along the critical advancement from idea, fluidic testing, bioanalytical validation and scale-up to commercial mass manufacture.
centrifugal microfluidics; Lab-on-a-Disc; fluidic integration; rotational flow control; valving
ENGINEERING, Automotive Engineering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.