Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cerebrospinal Fluid Protein Concentration in Japanese Healthy Older Volunteers

Version 1 : Received: 23 May 2021 / Approved: 24 May 2021 / Online: 24 May 2021 (10:38:05 CEST)

A peer-reviewed article of this Preprint also exists.

Yoshihara, T.; Zaitsu, M.; Ito, K.; Hanada, R.; Chung, E.; Yazawa, R.; Sakata, Y.; Furusho, K.; Tsukikawa, H.; Chiyoda, T.; Matsuki, S.; Irie, S. Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers. Int. J. Environ. Res. Public Health 2021, 18, 8683. Yoshihara, T.; Zaitsu, M.; Ito, K.; Hanada, R.; Chung, E.; Yazawa, R.; Sakata, Y.; Furusho, K.; Tsukikawa, H.; Chiyoda, T.; Matsuki, S.; Irie, S. Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers. Int. J. Environ. Res. Public Health 2021, 18, 8683.

Journal reference: Int. J. Environ. Res. Public Health 2021, 18, 8683
DOI: 10.3390/ijerph18168683

Abstract

The concentration of cerebrospinal fluid total protein (CSF-TP) is important for the diagnosis of neurological emergencies. Recently, some Western studies have shown that the current upper reference limit of CSF-TP is quite low for older patients. However, little is reported about the concentration of CSF-TP in older Asian population. In this study, we retrospectively analyzed the CSF-TP concentrations in Japanese healthy older volunteers. CSF samples in 69 healthy Japanese volunteers (age range: 55–73 years) were collected by lumbar puncture, and the data of CSF were retrospectively analyzed. The mean (standard deviation) CSF-TP was 41.7 (12.3) mg/dL. The older group (≥ 65 years old) had higher CSF-TP concentration than the younger group (55–64 years old). The 2.5th percentile and 97.5th percentile of CSF-TP were estimated as 22.5 and 73.2 mg/dL, respectively, which were higher than the current reference range in Japan (10–40 mg/dL).

Keywords

Cerebrospinal fluid; Total protein; Reference interval; Older population; Japanese healthy volunteer

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