Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Position Paper on the Applications of Ketogenic Diets in Patients with Headache: Consensus Statement

Cherubino Di Lorenzo
* ORCID logo ,
Giovanna Ballerini
,
Piero Barbanti
,
Andrea Bernardini
,
Giacomo D'Arrigo
,
Gabriella Egeo
,
Fabio Frediani
,
Riccardo Garbo
ORCID logo ,
Giulia Pierangeli
,
Addolorata Maria Pia Prudenzano
,
Nicoletta Rebaudengo
,
Grazia Semeraro
,
Giulio Sirianni
,
Mariarosaria Valente
,
Gianluca Coppola
ORCID logo ,
Mackenzie C. Cervenka
ORCID logo ,
Giovanni Spera
Version 1 : Received: 28 April 2021 / Approved: 30 April 2021 / Online: 30 April 2021 (15:38:37 CEST)

A peer-reviewed article of this Preprint also exists.

Di Lorenzo, C.; Ballerini, G.; Barbanti, P.; Bernardini, A.; D’Arrigo, G.; Egeo, G.; Frediani, F.; Garbo, R.; Pierangeli, G.; Prudenzano, M.P.; Rebaudengo, N.; Semeraro, G.; Sirianni, G.; Valente, M.; Coppola, G.; Cervenka, M.C.; Spera, G. Applications of Ketogenic Diets in Patients with Headache: Clinical Recommendations. Nutrients 2021, 13, 2307. Di Lorenzo, C.; Ballerini, G.; Barbanti, P.; Bernardini, A.; D’Arrigo, G.; Egeo, G.; Frediani, F.; Garbo, R.; Pierangeli, G.; Prudenzano, M.P.; Rebaudengo, N.; Semeraro, G.; Sirianni, G.; Valente, M.; Coppola, G.; Cervenka, M.C.; Spera, G. Applications of Ketogenic Diets in Patients with Headache: Clinical Recommendations. Nutrients 2021, 13, 2307.

Abstract

Headaches are among the most prevalent and disabling disorders and there are several patients’ unmet needs in current pharmacological options, while a growing interest is focusing on nutritional approaches as non-pharmacological treatments. Among these, the most promising seems to be the ketogenic diet (KD). Exactly 100 years ago, KD was used to treat pediatric forms of drug-resistant epilepsy, but progressively applications of this diet also involved adults and other neurological disorders. Evidence of KD effectiveness in migraine comes from 1928, but in the last years different groups of research and clinicians paid attention to this therapeutic option to treat patients with drug resistant migraine and cluster headache, and/or comorbid with metabolic syndrome. Here we describe all the existing evidence on the potential benefits of KDs in headaches, explore in deep all the potential mechanisms of action involved in the efficacy, and synthesize results of working meetings of an Italian panel of experts on this topic. Aim of the working group is the creation of a consensus on indications and clinical practice to treat with KDs patients with headache. The results here we present are the base for further improvement in the knowledge and application of KDs in the treatment of headaches.

Keywords

Ketogenic Diets; Ketosis; Ketones; Consensus Statement; Position Paper; Headache; Migraine; Cluster Headache

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.