Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Ursolic and Oleanolic Acids: Plant Metabolites with Neuromodulatory Potential

Version 1 : Received: 30 March 2021 / Approved: 31 March 2021 / Online: 31 March 2021 (16:17:04 CEST)

A peer-reviewed article of this Preprint also exists.

Gudoityte, E.; Arandarcikaite, O.; Mazeikiene, I.; Bendokas, V.; Liobikas, J. Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential. Int. J. Mol. Sci. 2021, 22, 4599. Gudoityte, E.; Arandarcikaite, O.; Mazeikiene, I.; Bendokas, V.; Liobikas, J. Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential. Int. J. Mol. Sci. 2021, 22, 4599.

Journal reference: Int. J. Mol. Sci. 2021, 22, 4599
DOI: 10.3390/ijms22094599

Abstract

Ursolic and oleanolic acids are secondary plant metabolites that are known to be involved in the plant defence system against water loss and pathogens. Nowadays these triterpenoids are also regarded as potential pharmaceutical compounds and there is mounting experimental data that either purified compounds or triterpenoid-enriched plant extracts exert various beneficial effects, including anti-oxidative, anti-inflammatory and anticancer, on model systems of both human or animal origin. Some of those effects have been linked to the ability of ursolic and oleanolic acids to modulate intracellular antioxidant systems and also inflammation- and cell death-related pathways. Therefore, our aim was to review the current knowledge about the distribution of ursolic and oleanolic acids in plants, bioavailability and pharmacokinetic properties of these triterpenoids and their derivatives, and to discuss their neuromodulatory effects in vitro and in vivo.

Keywords

ursolic acid; oleanolic acid; neuroprotection; ischaemia; neurodegeneration; Alzheimer’s disease; Parkinson’s disease; neuro-inflammation; cancer; glioblastoma

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