Working Paper Article Version 1 This version is not peer-reviewed

Anatomical Basis and Physiological and Biochemical Changes of Knee Joint Meniscus Injury

Version 1 : Received: 26 March 2021 / Approved: 29 March 2021 / Online: 29 March 2021 (13:10:31 CEST)

How to cite: ruan, C.; Yang, Y.; Li, Y.; Gao, J.; Wang, Y.; Liang, X.; Wang, L.; Yu, Y.; Lv, H.; Li, X. Anatomical Basis and Physiological and Biochemical Changes of Knee Joint Meniscus Injury. Preprints 2021, 2021030694 ruan, C.; Yang, Y.; Li, Y.; Gao, J.; Wang, Y.; Liang, X.; Wang, L.; Yu, Y.; Lv, H.; Li, X. Anatomical Basis and Physiological and Biochemical Changes of Knee Joint Meniscus Injury. Preprints 2021, 2021030694

Abstract

The meniscus is a meniscus-shaped fibrocartilage tissue located between the femur and tibia,it is mainly composed of meniscus cells and related extracellular matrix.The synovial limbus area of the knee joint capsule near the meniscus is divided into red areas with rich blood vessels and white areas with less blood supply according to the distribution of blood vessels,there is a transition zone called the red and white zone between the two;Red zone has better self-repair ability,The injury in this area can be treated by conservative treatment or surgical suture;Once the white area of the meniscus is torn and involves the free edge area,It is often necessary to partially remove the damaged meniscus.When most of the entire meniscus is severely torn and involved,not only the course of the disease is very long, but it cannot be repaired by sutures,Often a subtotal or total meniscus resection is required,whether it is a partial meniscus resection, a subtotal meniscus resection or a complete resection.In the later period, it may cause quadriceps atrophy and osteoarthritis (OA).OA is a refractory multi-system disease,involve the patient’s peripheral joints,it has high disability and teratogenicity, and is very harmful to human health.Chondrocyte pyrolysis, degradation, and inflammation play a vital role in the destruction of OA articular cartilage and chondrocyte apoptosis.Meniscus stem cells have strong proliferation and differentiation ability,has become one of the hot spots in the field of meniscus repair,this article studies the role of meniscal stem cells in the development of OA.

Subject Areas

Meniscal injury; anatomical basis; physiological changes; biochemical changes

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