Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Acute Myelogenous Leukemia Associated with MLL-SEPT6 Rearrangement and TRAF3, FGFR3 Mutation: A Pediatric Case Report and Review of the Literature

Version 1 : Received: 22 March 2021 / Approved: 24 March 2021 / Online: 24 March 2021 (16:20:43 CET)

How to cite: Chen, Y.; Pan, Y.; Zhang, L.; Chen, X.; Yang, W.; Guo, Y.; Zhu, X.; Chang, L. Acute Myelogenous Leukemia Associated with MLL-SEPT6 Rearrangement and TRAF3, FGFR3 Mutation: A Pediatric Case Report and Review of the Literature. Preprints 2021, 2021030601 (doi: 10.20944/preprints202103.0601.v1). Chen, Y.; Pan, Y.; Zhang, L.; Chen, X.; Yang, W.; Guo, Y.; Zhu, X.; Chang, L. Acute Myelogenous Leukemia Associated with MLL-SEPT6 Rearrangement and TRAF3, FGFR3 Mutation: A Pediatric Case Report and Review of the Literature. Preprints 2021, 2021030601 (doi: 10.20944/preprints202103.0601.v1).

Abstract

The MLL gene is a site of frequent rearrangement in acute leukemia with multiple fusion partners, but MLL-SEPT6 rearrangement is rare in clinical leukemia practice, and only 13 cases have been reported. We describe the case of an acute myelogenous leukemia child with MLL-SEPT6 rearrangement whose age of onset and accompanying gene mutations differs from previous reports. Considering the poor prognosis of leukemia children with MLL-SEPT6 rearrangement and the unsatisfactory results of existing treatments, the study of this case may provide new theories for diagnosis and treatment of MLL-SEPT6-associated childhood acute leukemia.

Subject Areas

MLL-SEPT6; TRAF3; FGFR3; Acute Myelogenous Leukemia; Child.

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.