Version 1
: Received: 22 March 2021 / Approved: 24 March 2021 / Online: 24 March 2021 (16:20:43 CET)
How to cite:
Chen, Y.; Pan, Y.; Zhang, L.; Chen, X.; Yang, W.; Guo, Y.; Zhu, X.; Chang, L. Acute Myelogenous Leukemia Associated with MLL-SEPT6 Rearrangement and TRAF3, FGFR3 Mutation: A Pediatric Case Report and Review of the Literature. Preprints2021, 2021030601. https://doi.org/10.20944/preprints202103.0601.v1
Chen, Y.; Pan, Y.; Zhang, L.; Chen, X.; Yang, W.; Guo, Y.; Zhu, X.; Chang, L. Acute Myelogenous Leukemia Associated with MLL-SEPT6 Rearrangement and TRAF3, FGFR3 Mutation: A Pediatric Case Report and Review of the Literature. Preprints 2021, 2021030601. https://doi.org/10.20944/preprints202103.0601.v1
Chen, Y.; Pan, Y.; Zhang, L.; Chen, X.; Yang, W.; Guo, Y.; Zhu, X.; Chang, L. Acute Myelogenous Leukemia Associated with MLL-SEPT6 Rearrangement and TRAF3, FGFR3 Mutation: A Pediatric Case Report and Review of the Literature. Preprints2021, 2021030601. https://doi.org/10.20944/preprints202103.0601.v1
APA Style
Chen, Y., Pan, Y., Zhang, L., Chen, X., Yang, W., Guo, Y., Zhu, X., & Chang, L. (2021). Acute Myelogenous Leukemia Associated with MLL-SEPT6 Rearrangement and TRAF3, FGFR3 Mutation: A Pediatric Case Report and Review of the Literature. Preprints. https://doi.org/10.20944/preprints202103.0601.v1
Chicago/Turabian Style
Chen, Y., Xiaofan Zhu and Lixian Chang. 2021 "Acute Myelogenous Leukemia Associated with MLL-SEPT6 Rearrangement and TRAF3, FGFR3 Mutation: A Pediatric Case Report and Review of the Literature" Preprints. https://doi.org/10.20944/preprints202103.0601.v1
Abstract
The MLL gene is a site of frequent rearrangement in acute leukemia with multiple fusion partners, but MLL-SEPT6 rearrangement is rare in clinical leukemia practice, and only 13 cases have been reported. We describe the case of an acute myelogenous leukemia child with MLL-SEPT6 rearrangement whose age of onset and accompanying gene mutations differs from previous reports. Considering the poor prognosis of leukemia children with MLL-SEPT6 rearrangement and the unsatisfactory results of existing treatments, the study of this case may provide new theories for diagnosis and treatment of MLL-SEPT6-associated childhood acute leukemia.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
