Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effects of Essential oils of Elettaria cardamomum Grown in India and Guatemala on Pseudomonas aeruginosa, Escherichia coli, and Gastrointestinal Disorders

Version 1 : Received: 20 January 2021 / Approved: 21 January 2021 / Online: 21 January 2021 (09:13:58 CET)

How to cite: Alam, A.; Rehman, N.U.; Ansari, M.N.; Palla, A. Effects of Essential oils of Elettaria cardamomum Grown in India and Guatemala on Pseudomonas aeruginosa, Escherichia coli, and Gastrointestinal Disorders. Preprints 2021, 2021010410 (doi: 10.20944/preprints202101.0410.v1). Alam, A.; Rehman, N.U.; Ansari, M.N.; Palla, A. Effects of Essential oils of Elettaria cardamomum Grown in India and Guatemala on Pseudomonas aeruginosa, Escherichia coli, and Gastrointestinal Disorders. Preprints 2021, 2021010410 (doi: 10.20944/preprints202101.0410.v1).

Abstract

The present study examined the volatile composition and antimicrobial and gastrointestinal activity of the essential oils of Elettaria cardamomum (L.) Maton harvested in India (EC-I) and Guatemala (EC-G). Monoterpene were present in higher concentration in EC-I (83.24%) than in EC-G (73.03%), whereas sesquiterpenes were present in higher concentration in EC-G (18.35%) than in EC-I (9.27%). Minimum inhibitory concentrations (MICs) of 0.5 and 0.1 mg/mL were demonstrated against Pseudomonas aeruginosa in EC-I and EC-G, respectively, whereas MICs of 0.125 and 1 mg/mL were demonstrated against Escherichia coli in EC-I and EC-G, respectively. The treatment with control had the highest kill-time potential, whereas the treatment with oils had shorter kill-time. EC-I was found to be more potent in the castor oil-induced diarrhoea model than EC-G. At 100 and 200 mg/kg, EC-I exhibited 40% and 80% protection, respectively, and EC-G exhibited 20% and 60% protection, respectively, in mice, whereas loperamide (positive control) exhibited 100% protection. In the in vitro experiments, EC-I inhibited both carbachol (CCh, 1 µM) and high K+ (80 mM)-induced contractions at significantly lower concentrations than EC-G. Thus, EC-I significantly inhibited P. aeruginosa and E. coli and exhibited more potent antidiarrheal and antispasmodic effects than EC-G.

Keywords

Elettaria cardamomum; GC-MS, compositions; antibacterial; antidiarrhoeal; antispasmodic

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