Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia

Version 1 : Received: 31 December 2020 / Approved: 4 January 2021 / Online: 4 January 2021 (10:19:48 CET)

How to cite: Themistocleous, C.; Webster, K.; Tsapkini, K. Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia. Preprints 2021, 2021010005 (doi: 10.20944/preprints202101.0005.v1). Themistocleous, C.; Webster, K.; Tsapkini, K. Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia. Preprints 2021, 2021010005 (doi: 10.20944/preprints202101.0005.v1).

Abstract

Transcranial direct current stimulation (tDCS) over the left Inferior Frontal Gyrus (IFG) was found to improve apraxia of speech (AOS) in post-stroke aphasia, speech fluency in adults who stutter, naming and spelling in primary progressive (PPA). This paper aims to determine whether tDCS over the left IFG coupled with AOS therapy improves speech fluency in patients with PPA more than sham. Eight patients with non-fluent PPA with AOS symptoms received either active or sham tDCS, along with speech therapy for 15 weekday sessions. Speech therapy consisted of repetition of increasing syllable-length words. Evaluations took place before, immediately after, and two months post-intervention. Words were segmented into vowels and consonants and the duration of each vowel and consonant was measured. Segmental duration was significantly shorter after tDCS than sham for both consonants and vowels. tDCS gains generalized to untrained words. The effects of tDCS sustained over two months post-treatment in trained words. Taken together, these results demonstrate that the tDCS over the left IFG facilitates speech production by reducing segmental duration. The results provide preliminary evidence that tDCS can maximize efficacy of speech therapy in non-fluent PPA with AOS.

Subject Areas

apraxia of speech (AOS); transcranial direct current stimulation (tDCS); primary progressive aphasia (PPA); inferior frontal gyrus (IFG); sound duration; brain stimulation

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