Working Paper Review Version 1 This version is not peer-reviewed

Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer

Version 1 : Received: 30 December 2020 / Approved: 31 December 2020 / Online: 31 December 2020 (07:20:49 CET)

A peer-reviewed article of this Preprint also exists.

Giuppi, M.; La Salvia, A.; Evangelista, J.; Ghidini, M. The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer. Biology 2021, 10, 146. Giuppi, M.; La Salvia, A.; Evangelista, J.; Ghidini, M. The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer. Biology 2021, 10, 146.

Journal reference: Biology 2021, 10, 146
DOI: 10.3390/biology10020146

Abstract

Gastric Cancer (GC) is the fifth most frequently diagnosed malignant tumor and the third cause of cancer mortality worldwide. For advanced GC, a large number of novel drugs and combinations have been tested, but results are still disappointing and the disease incurable in the majority of cases. In this regard, it is critical to investigate the molecular mechanisms underlying GC development. Angiogenesis is one of the hallmarks of cancer with a fundamental role in GC growth and progression and ramucirumab, a monoclonal antibody binding to vascular endothelial growth factor-2 (VEGFR-2) is approved in the treatment of advanced and pretreated GC. However, no predictive biomarkers for ramucirumab have been identified so far. MicroRNAs (miRNAs) are a class of evolutionally conserved single-stranded noncoding RNAs playing an important role, via post-transcriptional regulation, in essentially all biologic processes such as cell proliferation, differentiation, apoptosis, survival, invasion, and migration. Notably, in our review, we focused on miRNAs involved in angiogenic pathways in GC. Moreover, we evaluated the possible prognostic and predictive role of angiogenesis-related miRNAs as novel biomarkers of GC.

Keywords

MicroRNAs (miRNAs); gastric cancer; angiogenesis; VEGF; ramucirumab; biomarkers

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