Camacho-Hernández, D.A.; Nieto-Caballero, V.E.; León-Burguete, J.E.; Freyre-González, J.A. Partition Quantitative Assessment (PQA): A Quantitative Methodology to Assess the Embedded Noise in Clustered Omics and Systems Biology Data. Appl. Sci.2021, 11, 5999.
Camacho-Hernández, D.A.; Nieto-Caballero, V.E.; León-Burguete, J.E.; Freyre-González, J.A. Partition Quantitative Assessment (PQA): A Quantitative Methodology to Assess the Embedded Noise in Clustered Omics and Systems Biology Data. Appl. Sci. 2021, 11, 5999.
Camacho-Hernández, D.A.; Nieto-Caballero, V.E.; León-Burguete, J.E.; Freyre-González, J.A. Partition Quantitative Assessment (PQA): A Quantitative Methodology to Assess the Embedded Noise in Clustered Omics and Systems Biology Data. Appl. Sci.2021, 11, 5999.
Camacho-Hernández, D.A.; Nieto-Caballero, V.E.; León-Burguete, J.E.; Freyre-González, J.A. Partition Quantitative Assessment (PQA): A Quantitative Methodology to Assess the Embedded Noise in Clustered Omics and Systems Biology Data. Appl. Sci. 2021, 11, 5999.
Abstract
Identifying groups that share common features among datasets through clustering analysis is a typical problem in many fields of science, particularly in post-omics and systems biology research. In respect of this, quantifying how a measure can cluster or organize intrinsic groups is important since currently there is no statistical evaluation of how ordered is, or how much noise is embedded in the resulting clustered vector. Many of the literature focuses on how well the clustering algorithm orders the data, with several measures regarding external and internal statistical measures; but none measure has been developed to statistically quantify the noise in an arranged vector posterior a clustering algorithm, i.e., how much of the clustering is due to randomness. Here, we present a quantitative methodology, based on autocorrelation, to assess this problem.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
