Version 1
: Received: 22 December 2020 / Approved: 24 December 2020 / Online: 24 December 2020 (07:54:21 CET)
How to cite:
Awan, Z.A.; Amoudi, S.M.A.; Saboor, M.; Alkhaldy, H.Y. Isolated Neutropenia/Benign Ethnic Neutropenia: A Common Clinical and Laboratory Finding in Southern and Southwestern Saudi Arabia. Preprints2020, 2020120604. https://doi.org/10.20944/preprints202012.0604.v1
Awan, Z.A.; Amoudi, S.M.A.; Saboor, M.; Alkhaldy, H.Y. Isolated Neutropenia/Benign Ethnic Neutropenia: A Common Clinical and Laboratory Finding in Southern and Southwestern Saudi Arabia. Preprints 2020, 2020120604. https://doi.org/10.20944/preprints202012.0604.v1
Awan, Z.A.; Amoudi, S.M.A.; Saboor, M.; Alkhaldy, H.Y. Isolated Neutropenia/Benign Ethnic Neutropenia: A Common Clinical and Laboratory Finding in Southern and Southwestern Saudi Arabia. Preprints2020, 2020120604. https://doi.org/10.20944/preprints202012.0604.v1
APA Style
Awan, Z.A., Amoudi, S.M.A., Saboor, M., & Alkhaldy, H.Y. (2020). Isolated Neutropenia/Benign Ethnic Neutropenia: A Common Clinical and Laboratory Finding in Southern and Southwestern Saudi Arabia. Preprints. https://doi.org/10.20944/preprints202012.0604.v1
Chicago/Turabian Style
Awan, Z.A., Muhammad Saboor and Husain Y. Alkhaldy. 2020 "Isolated Neutropenia/Benign Ethnic Neutropenia: A Common Clinical and Laboratory Finding in Southern and Southwestern Saudi Arabia" Preprints. https://doi.org/10.20944/preprints202012.0604.v1
Abstract
Objectives: Isolated mild neutropenia is a common clinical problem. The current study aims to validate our previous findings regarding the high prevalence of isolated neutropenia in Southern and Southwestern Saudi Arabia and explore the effect of altitude or regional differences. Methods: In this retrospective cross-sectional study, laboratory results of a commercial laboratory were screened over a period of 5 years (2016–2020) in seven different cities in South and southwestern Saudi Arabia. Participants’ laboratory investigations were reviewed and excluded for any ab-normal complete blood count, renal profile, liver profile, lipid profile, thyroid function test, fasting blood glucose, or HbA1c findings. Descriptive analysis and 95th percentile range were calculated using standard statistical methods. Results: A total of 91,880 complete blood count results were included in the final analysis. isolated neutropenia is common laboratory finding, with a prevalence ranging from 11-23%. The 2.5th percentile of the neutrophil count was lower than 1.5×109/L in all seven cities. Conclusions: Mild to moderate neutropenia is common in Southern and Southwestern Saudi Arabia. Benign ethnic neutropenia (BEN) may explain this high prevalence. Since BEN has no clinical significance, the reference range for normal neutrophil counts needs to be adjusted to reflect the effect of BEN.
Keywords
isolated neutropenia; benign ethnic neutropenia; reference intervals; Saudi Arabia
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
