Version 1
: Received: 20 December 2020 / Approved: 21 December 2020 / Online: 21 December 2020 (11:12:31 CET)
Version 2
: Received: 25 March 2021 / Approved: 25 March 2021 / Online: 25 March 2021 (15:14:06 CET)
Version 3
: Received: 14 November 2021 / Approved: 15 November 2021 / Online: 15 November 2021 (13:34:33 CET)
How to cite:
Marsellach, X. The Principle of Continuous Biological Information Flow as the Fundamental Foundation for the Biological Sciences. Implications for Ageing Research. Preprints2020, 2020120506 (doi: 10.20944/preprints202012.0506.v2).
Marsellach, X. The Principle of Continuous Biological Information Flow as the Fundamental Foundation for the Biological Sciences. Implications for Ageing Research. Preprints 2020, 2020120506 (doi: 10.20944/preprints202012.0506.v2).
Cite as:
Marsellach, X. The Principle of Continuous Biological Information Flow as the Fundamental Foundation for the Biological Sciences. Implications for Ageing Research. Preprints2020, 2020120506 (doi: 10.20944/preprints202012.0506.v2).
Marsellach, X. The Principle of Continuous Biological Information Flow as the Fundamental Foundation for the Biological Sciences. Implications for Ageing Research. Preprints 2020, 2020120506 (doi: 10.20944/preprints202012.0506.v2).
Abstract
The current state of biological knowledge contains an unresolved paradox: life as a continuity in the face of the phenomena of ageing. In this manuscript I propose a theoretical framework that offers a solution for this apparent contradiction. The framework proposed is based on a rethinking of what ageing is at a molecular level, as well as on a rethinking of the mechanisms in charge of the flow of information from one generation to the following ones. I propose an information-based conception of ageing instead of the widely accepted damage-based conception of ageing and propose a full recovery of the chromosome theory of inheritance to describe the intergenerational flow of information. Altogether the proposed framework allows a precise and unique definition of what life is: a continuous flow of biological information. The proposed framework also implies that ageing is merely a consequence of the way in which epigenetically-coded phenotypic characteristics are passed from one generation to the next ones.
Keywords
Ageing; Epigenetics
Subject
LIFE SCIENCES, Biochemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
25 March 2021
Commenter:
Xavi Marsellach
Commenter's Conflict of Interests:
Author
Comment:
I have rewritten most of the last half part of the manuscript to make its reading more straightforward and to try to make the main ideas of the paper in a more understandable way.
Commenter: Xavi Marsellach
Commenter's Conflict of Interests: Author