Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Skeletal Muscle and the Maintenance of Vitamin D Status

Version 1 : Received: 29 September 2020 / Approved: 30 September 2020 / Online: 30 September 2020 (08:11:15 CEST)

How to cite: Fraser, D.R.; Rybchyn, M.S.; Abboud, M.; Puglisi, D.A.; Gordon-Thomson, C.; Brennan-Speranza, T.C.; Mason, R.S. Skeletal Muscle and the Maintenance of Vitamin D Status. Preprints 2020, 2020090727 (doi: 10.20944/preprints202009.0727.v1). Fraser, D.R.; Rybchyn, M.S.; Abboud, M.; Puglisi, D.A.; Gordon-Thomson, C.; Brennan-Speranza, T.C.; Mason, R.S. Skeletal Muscle and the Maintenance of Vitamin D Status. Preprints 2020, 2020090727 (doi: 10.20944/preprints202009.0727.v1).

Abstract

Vitamin D, unlike the micronutrients, vitamins A, E and K, is largely obtained, not from food, but by the action of solar UV light on its precursor, 7-dehydrocholesterol, in skin. With the decline in UV light intensity in winter, most skin production of vitamin D occurs in summer. Because no defined storage organ or tissue has been found for vitamin D, it has been assumed that adequate vitamin D status in winter can only be maintained by oral supplementation. Skeletal muscle cells have now been shown to incorporate the vitamin D-binding protein (DBP) from blood into the cell cytoplasm where it binds to cytoplasmic actin. This intracellular DBP provides an array of specific binding sites for 25-hydroxyvitamin D (25(OH)D) which diffuses into the cell from the extracellular fluid. When intracellular DBP undergoes proteolytic breakdown, the bound 25(OH)D is then released and diffuses back into blood. This uptake and release of 25(OH)D by muscle, accounts for the very long half-life of this metabolite in the circulation. As 25(OH)D concentration in blood declines in winter, its cycling in and out of muscle cells appears to be upregulated. Parathyroid hormone is the most likely factor enhancing the repeated cycling of 25(OH)D between skeletal muscle and blood. This mechanism appears to have evolved to maintain adequate vitamin D status in winter.

Subject Areas

vitamin D; muscle; parathyroid hormone; vitamin D-binding protein

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