Harris, L.J.; Patel, K.; Martin, M. Novel Therapies for Relapsed or Refractory Diffuse Large B-Cell Lymphoma. Int. J. Mol. Sci.2020, 21, 8553.
Harris, L.J.; Patel, K.; Martin, M. Novel Therapies for Relapsed or Refractory Diffuse Large B-Cell Lymphoma. Int. J. Mol. Sci. 2020, 21, 8553.
Harris, L.J.; Patel, K.; Martin, M. Novel Therapies for Relapsed or Refractory Diffuse Large B-Cell Lymphoma. Int. J. Mol. Sci.2020, 21, 8553.
Harris, L.J.; Patel, K.; Martin, M. Novel Therapies for Relapsed or Refractory Diffuse Large B-Cell Lymphoma. Int. J. Mol. Sci. 2020, 21, 8553.
Abstract
The most common type of non-Hodgkin lymphoma in adults is diffuse large B-cell (DLBCL). There is a historical unmet need for more effective therapies in the 2nd and 3rd line setting. Emerging immunochemotherapies have shown activity in small studies of heavily pre-treated patients with prolonged remissions achieved in some patients. Anti-CD19 CAR (chimeric antigen receptor) T cells are potentially curative in the 3rd line and beyond setting and are under investigation in earlier lines of therapy.1 Antibody-drug conjugates (ADC’s) such as polatuzumab vedotin targeting the pan-B-cell marker CD79b has proven effectiveness in multiply-relapsed DLBCL patients. Tafasitamab (MOR208) is an anti-CD19 monoclonal antibody producing prolonged remissions when combined with Lenalidomide in patients who were not candidates for salvage chemotherapy or autologous stem cell transplant. Selinexor, an oral, small-molecule selective inhibitor of XPO1-mediated nuclear export (SINE), demonstrated prolonged activity against heavily-pretreated DLBCL without cumulative toxicity and is being investigated as part of an oral, chemotherapy-free regimen for relapsed aggressive lymphoma. This article reviews current strategies and novel therapies for relapsed/refractory DLBCL.
Keywords
Relapsed or Refractory Diffuse Large B Cell Lymphoma, DLBLC, immunotherapy, chemotherapy-free regimen
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
