Version 1
: Received: 20 September 2020 / Approved: 22 September 2020 / Online: 22 September 2020 (08:17:48 CEST)
How to cite:
Akhlaq, M.; Ullah, I.; Nawaz, A.; Safdar, M.; Azad, A.K.; Abbas, S.A.; Mohammed Helaluddin, A.B. Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology. Preprints2020, 2020090510. https://doi.org/10.20944/preprints202009.0510.v1
Akhlaq, M.; Ullah, I.; Nawaz, A.; Safdar, M.; Azad, A.K.; Abbas, S.A.; Mohammed Helaluddin, A.B. Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology. Preprints 2020, 2020090510. https://doi.org/10.20944/preprints202009.0510.v1
Akhlaq, M.; Ullah, I.; Nawaz, A.; Safdar, M.; Azad, A.K.; Abbas, S.A.; Mohammed Helaluddin, A.B. Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology. Preprints2020, 2020090510. https://doi.org/10.20944/preprints202009.0510.v1
APA Style
Akhlaq, M., Ullah, I., Nawaz, A., Safdar, M., Azad, A.K., Abbas, S.A., & Mohammed Helaluddin, A.B. (2020). Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology. Preprints. https://doi.org/10.20944/preprints202009.0510.v1
Chicago/Turabian Style
Akhlaq, M., Syed Atif Abbas and Abul Bashar Mohammed Helaluddin. 2020 "Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology" Preprints. https://doi.org/10.20944/preprints202009.0510.v1
Abstract
The purpose of current research work was to formulate and typify gelatin and poly(vinyl) alcohol (Gel/PVA) hydrogel which would be highly pH-responsive and can able to accomplish targeted delivery of methotrexate in order to treat the colo-rectal pathologies. The primed gel/pva hydrogel discs were subjected to various physicochemical techniques i.e. swelling, diffusion co-efficient, sol-gel analysis and porosity using three altered sorts of pH (1.2, 6.8 & 7.4) phosphate buffer solutions for assessment/evaluation, and their characterization was done through Fourier transform infrared spectroscopy (FTIR) and thermal gravimetric analysis (TGA). Shape alteration and controlled methotrexate of release of Gel/PVA hydrogel have been done using three type of pH (1.2, 6.8 & 7.4) phosphate buffer mediums. Methotrexate was loaded through in-situ drug loading method due to hydrophobicity. Different kinetic models (first order & zero order kinetic), Higuchi model and Krosmere peppas model/Power law were applied to manipulate the drug release data. Physicochemical evaluation tests and drug release profile results were found insignificant (p< 0.05) in various pH mediums and dependent upon polymers concentration pH of medium and cross-linker amount. Kinetic model disclosed that release of methotrexate from Gel/PVA hydrogel follow non-Fickian diffusion method. It became concluded from this research work that release of methotrexate Gel/PVA hydrogel in targeted colon area can be achieved for treating colo-rectal disorders.
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
*
,
*
