Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology

Version 1 : Received: 20 September 2020 / Approved: 22 September 2020 / Online: 22 September 2020 (08:17:48 CEST)

How to cite: Akhlaq, M.; Ullah, I.; Nawaz, A.; Safdar, M.; Azad, A.K.; Abbas, S.A.; Mohammed Helaluddin, A.B. Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology. Preprints 2020, 2020090510 (doi: 10.20944/preprints202009.0510.v1). Akhlaq, M.; Ullah, I.; Nawaz, A.; Safdar, M.; Azad, A.K.; Abbas, S.A.; Mohammed Helaluddin, A.B. Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology. Preprints 2020, 2020090510 (doi: 10.20944/preprints202009.0510.v1).

Abstract

The purpose of current research work was to formulate and typify gelatin and poly(vinyl) alcohol (Gel/PVA) hydrogel which would be highly pH-responsive and can able to accomplish targeted delivery of methotrexate in order to treat the colo-rectal pathologies. The primed gel/pva hydrogel discs were subjected to various physicochemical techniques i.e. swelling, diffusion co-efficient, sol-gel analysis and porosity using three altered sorts of pH (1.2, 6.8 & 7.4) phosphate buffer solutions for assessment/evaluation, and their characterization was done through Fourier transform infrared spectroscopy (FTIR) and thermal gravimetric analysis (TGA). Shape alteration and controlled methotrexate of release of Gel/PVA hydrogel have been done using three type of pH (1.2, 6.8 & 7.4) phosphate buffer mediums. Methotrexate was loaded through in-situ drug loading method due to hydrophobicity. Different kinetic models (first order & zero order kinetic), Higuchi model and Krosmere peppas model/Power law were applied to manipulate the drug release data. Physicochemical evaluation tests and drug release profile results were found insignificant (p< 0.05) in various pH mediums and dependent upon polymers concentration pH of medium and cross-linker amount. Kinetic model disclosed that release of methotrexate from Gel/PVA hydrogel follow non-Fickian diffusion method. It became concluded from this research work that release of methotrexate Gel/PVA hydrogel in targeted colon area can be achieved for treating colo-rectal disorders.

Subject Areas

Hydrogel; pH-responsive; colon; targeted delivery; methotrexate

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