Version 1
: Received: 13 September 2020 / Approved: 13 September 2020 / Online: 13 September 2020 (16:16:59 CEST)
Version 2
: Received: 18 September 2020 / Approved: 19 September 2020 / Online: 19 September 2020 (04:49:18 CEST)
Version 3
: Received: 21 October 2020 / Approved: 22 October 2020 / Online: 22 October 2020 (10:43:56 CEST)
Version 4
: Received: 1 December 2020 / Approved: 2 December 2020 / Online: 2 December 2020 (11:45:50 CET)
How to cite:
Gomes, I.C.; Karmirian, K.; Oliveira, J.; Pedrosa, C.; Rosman, F.C.; Chimelli, L.; Rehen, S. SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant Submitted to Complete Autopsy. Preprints2020, 2020090297
Gomes, I.C.; Karmirian, K.; Oliveira, J.; Pedrosa, C.; Rosman, F.C.; Chimelli, L.; Rehen, S. SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant Submitted to Complete Autopsy. Preprints 2020, 2020090297
Cite as:
Gomes, I.C.; Karmirian, K.; Oliveira, J.; Pedrosa, C.; Rosman, F.C.; Chimelli, L.; Rehen, S. SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant Submitted to Complete Autopsy. Preprints2020, 2020090297
Gomes, I.C.; Karmirian, K.; Oliveira, J.; Pedrosa, C.; Rosman, F.C.; Chimelli, L.; Rehen, S. SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant Submitted to Complete Autopsy. Preprints 2020, 2020090297
Abstract
Coronavirus disease 2019 (COVID-19) was initially characterized as a respiratory illness. Neurological manifestations were reported mostly in severely affected patients. Routes for brain infection and the presence of virus particles in situ have not been well described, raising controversy about how the virus causes neurological symptoms. Here, we report the autopsy findings of a 1-year old infant with COVID-19. In addition to pneumonitis, meningitis and multiple organ damage related to thrombosis, a previous encephalopathy may have contributed to additional cerebral damage. SARS-CoV-2 infected the choroid plexus, ventricles, and cerebral cortex. This is the first evidence of SARS-CoV-2 detection in an infant post-mortem brain.
Subject Areas
SARS-CoV-2; COVID-19; CNS; infant; Choroid plexus
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Stevens Rehen
Commenter's Conflict of Interests: Author
Photos with better resolution.
Fixing errors in the percentage of cerebral atrophy and "References".