SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant Submitted to Complete Autopsy

Ismael Carlos Gomes; Karina Karmirian; Julia Oliveira; Carolina Pedrosa; Fernando Colonna Rosman; Leila Chimelli; Stevens Rehen

Working Paper Case Report Version 2 This version is not peer-reviewed

Version 1 : Received: 13 September 2020 / Approved: 13 September 2020 / Online: 13 September 2020 (16:16:59 CEST)
Version 2 : Received: 18 September 2020 / Approved: 19 September 2020 / Online: 19 September 2020 (04:49:18 CEST)
Version 3 : Received: 21 October 2020 / Approved: 22 October 2020 / Online: 22 October 2020 (10:43:56 CEST)
Version 4 : Received: 1 December 2020 / Approved: 2 December 2020 / Online: 2 December 2020 (11:45:50 CET)
Version 5 : Received: 11 March 2021 / Approved: 15 March 2021 / Online: 15 March 2021 (13:03:33 CET)

Coronavirus disease 2019 (COVID-19) was initially characterized as a respiratory illness. Neurological manifestations were reported mostly in severely affected patients. Routes for brain infection and the presence of virus particles in situ have not been well described, raising controversy about how the virus causes neurological symptoms. Here, we report the autopsy findings of a 1-year old infant with COVID-19. In addition to pneumonitis, meningitis and multiple organ damage related to thrombosis, a previous encephalopathy may have contributed to additional cerebral damage. SARS-CoV-2 infected the choroid plexus, ventricles, and cerebral cortex. This is the first evidence of SARS-CoV-2 detection in an infant post-mortem brain.

SARS-CoV-2; COVID-19; CNS; infant; Choroid plexus

Comment 1

Received: 19 September 2020
Commenter: Stevens Rehen
Commenter's Conflict of Interests: Author

Comment: Small corrections in "Case report" and "Discussion", since new data were received by our group.

Photos with better resolution.

Fixing errors in the percentage of cerebral atrophy and "References".

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SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant Submitted to Complete Autopsy

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