Working Paper Case Report Version 2 This version is not peer-reviewed

SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant Submitted to Complete Autopsy

Version 1 : Received: 13 September 2020 / Approved: 13 September 2020 / Online: 13 September 2020 (16:16:59 CEST)
Version 2 : Received: 18 September 2020 / Approved: 19 September 2020 / Online: 19 September 2020 (04:49:18 CEST)
Version 3 : Received: 21 October 2020 / Approved: 22 October 2020 / Online: 22 October 2020 (10:43:56 CEST)
Version 4 : Received: 1 December 2020 / Approved: 2 December 2020 / Online: 2 December 2020 (11:45:50 CET)
Version 5 : Received: 11 March 2021 / Approved: 15 March 2021 / Online: 15 March 2021 (13:03:33 CET)

A peer-reviewed article of this Preprint also exists.

Journal reference: The Lancet Regional Health - Americas 2021
DOI: 10.1016/j.lana.2021.100046

Abstract

Coronavirus disease 2019 (COVID-19) was initially characterized as a respiratory illness. Neurological manifestations were reported mostly in severely affected patients. Routes for brain infection and the presence of virus particles in situ have not been well described, raising controversy about how the virus causes neurological symptoms. Here, we report the autopsy findings of a 1-year old infant with COVID-19. In addition to pneumonitis, meningitis and multiple organ damage related to thrombosis, a previous encephalopathy may have contributed to additional cerebral damage. SARS-CoV-2 infected the choroid plexus, ventricles, and cerebral cortex. This is the first evidence of SARS-CoV-2 detection in an infant post-mortem brain.

Keywords

SARS-CoV-2; COVID-19; CNS; infant; Choroid plexus

Subject

MEDICINE & PHARMACOLOGY, Clinical Neurology

Comments (1)

Comment 1
Received: 19 September 2020
Commenter: Stevens Rehen
Commenter's Conflict of Interests: Author
Comment: Small corrections in "Case report" and "Discussion", since new data were received by our group.

Photos with better resolution.

Fixing errors in the percentage of cerebral atrophy and "References".
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