Preprint
Technical Note
Noisy Genome Data and Faulty Clade Statistics Undermine Conclusions on SARS-CoV-2 Evolution and Strain Typing in the Brazilian Epidemy: A Technical Note
Submitted:
27 August 2020
Posted:
30 August 2020
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Abstract
We show that low quality of all 427 Brazilian SARS-CoV-2 genomes recently published in Science (1) challenges their phylogenetic inference and may lead to incorrect typing of viral strains in clades with no statistical support. Absence of basecalling quality in genome assemblies and proper phylogeny parameter estimates preclude the assessment of signal-to-noise ratio in the data, downstream analysis and conclusions.
Keywords:
SARS-CoV-2
; COVID-19
; Viral Evolution
Preprints on COVID-19 and SARS-CoV-2
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
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