Version 1
: Received: 25 August 2020 / Approved: 27 August 2020 / Online: 27 August 2020 (12:39:30 CEST)
Version 2
: Received: 26 February 2021 / Approved: 4 March 2021 / Online: 4 March 2021 (10:17:15 CET)
Jayanta Kumar Das and Swarup Roy. 2021. A study on non-synonymous mutational patterns in structural proteins of SARS-CoV-2. Genome. 64(7): 665-678. https://doi.org/10.1139/gen-2020-0157
Jayanta Kumar Das and Swarup Roy. 2021. A study on non-synonymous mutational patterns in structural proteins of SARS-CoV-2. Genome. 64(7): 665-678. https://doi.org/10.1139/gen-2020-0157
Jayanta Kumar Das and Swarup Roy. 2021. A study on non-synonymous mutational patterns in structural proteins of SARS-CoV-2. Genome. 64(7): 665-678. https://doi.org/10.1139/gen-2020-0157
Jayanta Kumar Das and Swarup Roy. 2021. A study on non-synonymous mutational patterns in structural proteins of SARS-CoV-2. Genome. 64(7): 665-678. https://doi.org/10.1139/gen-2020-0157
Abstract
SARS-CoV-2 is mutating and creating divergent variants across the world. An in-depth investigation of the amino acid substitution in the genomic signature of SARS-CoV-2 proteins is highly essential for understanding its host adaptation and infection biology. A total of 9587 SARS-CoV-2 structural protein sequences collected from 49 different countries are used to characterize protein-wise variants, substitution pattern (type and location), and major substitution changes. The majority of the substitutions are distinct, occurred mostly in a particular location, and leads to a change in amino acid's biochemical properties. In terms of mutational changes, Envelope (E) and Membrane (M) proteins are relatively stable than Nucleocapsid (N) and Spike (S) proteins. Several co-occurrence substitutions are observed, particularly in S and N proteins. Substitution specific to active sub-domains reveals that Heptapeptide Repeat, Fusion peptides, Transmembrane in S protein, and N-terminal and C-terminal domains in N protein are remarkably mutated, and also found few deleterious mutations in these domains.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
4 March 2021
Commenter:
Jayanta Das
Commenter's Conflict of Interests:
Author
Comment:
The dataset is kept unchanged. The analysis of results is partly changed, partly removed and modified. Further, we added a few more comparative results with the simulated dataset.
Commenter: Jayanta Das
Commenter's Conflict of Interests: Author