Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

A Study on Non-Synonymous Mutational Patterns in Structural Proteins of SARS-COV-2

Version 1 : Received: 25 August 2020 / Approved: 27 August 2020 / Online: 27 August 2020 (12:39:30 CEST)
Version 2 : Received: 26 February 2021 / Approved: 4 March 2021 / Online: 4 March 2021 (10:17:15 CET)

How to cite: Das, J.; Roy, S. A Study on Non-Synonymous Mutational Patterns in Structural Proteins of SARS-COV-2. Preprints 2020, 2020080621 (doi: 10.20944/preprints202008.0621.v2). Das, J.; Roy, S. A Study on Non-Synonymous Mutational Patterns in Structural Proteins of SARS-COV-2. Preprints 2020, 2020080621 (doi: 10.20944/preprints202008.0621.v2).

Abstract

SARS-CoV-2 is mutating and creating divergent variants across the world. An in-depth investigation of the amino acid substitution in the genomic signature of SARS-CoV-2 proteins is highly essential for understanding its host adaptation and infection biology. A total of 9587 SARS-CoV-2 structural protein sequences collected from 49 different countries are used to characterize protein-wise variants, substitution pattern (type and location), and major substitution changes. The majority of the substitutions are distinct, occurred mostly in a particular location, and leads to a change in amino acid's biochemical properties. In terms of mutational changes, Envelope (E) and Membrane (M) proteins are relatively stable than Nucleocapsid (N) and Spike (S) proteins. Several co-occurrence substitutions are observed, particularly in S and N proteins. Substitution specific to active sub-domains reveals that Heptapeptide Repeat, Fusion peptides, Transmembrane in S protein, and N-terminal and C-terminal domains in N protein are remarkably mutated, and also found few deleterious mutations in these domains.

Keywords

Clustering; Mutation; Amino acid substitution; Structural proteins;Biochemical properties;Functional sub-domains

Comments (1)

Comment 1
Received: 4 March 2021
Commenter: Jayanta Das
Commenter's Conflict of Interests: Author
Comment: The dataset is kept unchanged. The analysis of results is partly changed, partly removed and modified. Further, we added a few more comparative results with the simulated dataset.
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