Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives

Version 1 : Received: 20 August 2020 / Approved: 24 August 2020 / Online: 24 August 2020 (10:03:22 CEST)

A peer-reviewed article of this Preprint also exists.

Alshamari, A.; Al-Qudah, M.; Hamadeh, F.; Al-Momani, L.; Abu-Orabi, S. Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives. Molecules 2020, 25, 4271. Alshamari, A.; Al-Qudah, M.; Hamadeh, F.; Al-Momani, L.; Abu-Orabi, S. Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives. Molecules 2020, 25, 4271.

Journal reference: Molecules 2020, 25, 4271
DOI: 10.3390/molecules25184271

Abstract

A series of derivatives of trans-3-(2,4,6-trimethoxy phenyl)-4,5-dihydro isoxazolo-4,5-bis(aroylcarbohydrazide) and of trans-3-(2,4,6-trimethoxyphenyl)4,5-dihydroisoxazolo-4,5-bis[carbonyl-(4’phenyl)thiosemi- carbazide (9) were synthesized from trans-3-(2,4,6-trimethoxyphenyl)-4,5-dihydro-4,5-bis(hydrazenocarbonyl) Isoxazole (8). The structures of the Compounds were elucidated by elemental and spectral (IR, NMR, and MS) analysis. The compound 9 show activity against some bacterial species. Whereas, no activity was observed for compounds 10a, 10b and 10c against all bacterial species. The antioxidant activity of new compounds has been screened. Compound 9 showed higher antioxidant activity using the DPPH and ATBS method.

Subject Areas

Isoxazolines; nitrile oxide; 1,3-dipolar cycloaddition; antibacterial activity; antioxidant activity

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