Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effect of Lactate and Lactate Clearance Condition on the Prognosis of Sepsis in Children

Version 1 : Received: 27 July 2020 / Approved: 30 July 2020 / Online: 30 July 2020 (11:23:48 CEST)

How to cite: Hasan, D.M.K.; Evan, S.H.; Karim, M.R.; Men, X.Y.; Huifeng, Z.; Yuan, C. Effect of Lactate and Lactate Clearance Condition on the Prognosis of Sepsis in Children. Preprints 2020, 2020070718 (doi: 10.20944/preprints202007.0718.v1). Hasan, D.M.K.; Evan, S.H.; Karim, M.R.; Men, X.Y.; Huifeng, Z.; Yuan, C. Effect of Lactate and Lactate Clearance Condition on the Prognosis of Sepsis in Children. Preprints 2020, 2020070718 (doi: 10.20944/preprints202007.0718.v1).

Abstract

Objectives: To investigate the value of early lactate dynamic monitoring index in predicting prognosis of patients with sepsis and septic shock. Methods: We performed our test on 50 patients. Out of 50 patients, 28 are male, and 22 are female. Prospectively studied pediatric patients with septic shock were performed. Vital signs, Lactate clearance, were obtained at presentation 6 h, 12 h, 24 h over the first 48 h of hospitalization. The therapy received, outcome parameters of mortality and duration of hospitalization were recorded. Results: The statistical data and comparative analysis showed that an average of 16.88 days after admission, 5 patients have died, 17 patients are poorly prognosis leaves the hospital, and the remaining 28 are recovered and discharged. The primary outcome variable of mean 16 days hospitalization mortality rate was 10%. Poor prognosis 34% and fully recovery 56 % were observed. In this retrospective cohort study, a lactate level of more than 2.5mmol/L was the best threshold to predict 28-day mortality among severe sepsis and septic shock patients. In our research, we found mean LC 6 h 3.08mmol/L, and after 48 h mean it is 1.79mmol/L. Significant LC 6 h found, which is 8.08mmol/L in the death group patient where 48 h mmol/L shows significant high. Poor prognosis also presents a clinical increase of lactate level high in the LC 6 h analysis, which is 3.32mmol/L. Recovered patients showed a significant improvement after administering treatment depending on the patient organ involvement and good decrease of lactate reports achieved, which is 1.20mmol/L, where admission reports show it was 1.91mmol/L in LC 6 h. Mean Heart rate 94/51mmhg, pulse 119, temperature 39℃, respiratory rate 32.26, and urine output 456 ml recorded during our study. Death patient shows a remarkable detonation of those reports but has a significant clinical report with the recovered patients. Conclusion: The early lactate dynamic monitoring index has a high value in predicting sepsis and septic shock patients' prognosis, thus worth popularizing.

Subject Areas

Sepsis, Septic shock, Lactic acid, Dynamic monitoring, Prognosis

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