Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

Mitochondria Determine Response to Anti-PD-1 Therapy: An Evidence-based Hypothesis

Version 1 : Received: 3 June 2020 / Approved: 4 June 2020 / Online: 4 June 2020 (13:54:40 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: Mitochondrion 2021
DOI: 10.1016/j.mito.2021.12.001


It has been demonstrated that a decrease in cellular adenosine triphosphate (c-ATP) causes cellular dysfunction. T-cells are not an exception. One of their roles is to properly detect and eliminate cancer cells. These processes occur at the expense of ATP. Therefore, it can be concluded that a decrease in c-ATP can defect T-cell function and promote cancer evolution. In this article, we provide a hypothesis to describe the correlation between the expression of PD-1 protein on T-cells and their c-ATP levels. Moreover, we present the possible predictive factors of Anti–PD(L)-1 therapy which has not yet been determined definitely.


T-lymphocytes; programmed cell death protein-1; mitochondria; adenosine triphosphate

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