Version 1
: Received: 29 May 2020 / Approved: 31 May 2020 / Online: 31 May 2020 (16:28:19 CEST)
How to cite:
Acosta Saltos, A.; Carolina Acosta Saltos, F. SARS-CoV2 at the Alveolar Epithelial-Endothelial Interface – A Hypothesis for the Pathogenesis of COVID-19. Preprints2020, 2020050480. https://doi.org/10.20944/preprints202005.0480.v1
Acosta Saltos, A.; Carolina Acosta Saltos, F. SARS-CoV2 at the Alveolar Epithelial-Endothelial Interface – A Hypothesis for the Pathogenesis of COVID-19. Preprints 2020, 2020050480. https://doi.org/10.20944/preprints202005.0480.v1
Acosta Saltos, A.; Carolina Acosta Saltos, F. SARS-CoV2 at the Alveolar Epithelial-Endothelial Interface – A Hypothesis for the Pathogenesis of COVID-19. Preprints2020, 2020050480. https://doi.org/10.20944/preprints202005.0480.v1
APA Style
Acosta Saltos, A., & Carolina Acosta Saltos, F. (2020). SARS-CoV2 at the Alveolar Epithelial-Endothelial Interface – A Hypothesis for the Pathogenesis of COVID-19. Preprints. https://doi.org/10.20944/preprints202005.0480.v1
Chicago/Turabian Style
Acosta Saltos, A. and Francia Carolina Acosta Saltos. 2020 "SARS-CoV2 at the Alveolar Epithelial-Endothelial Interface – A Hypothesis for the Pathogenesis of COVID-19" Preprints. https://doi.org/10.20944/preprints202005.0480.v1
Abstract
Severe COVID-19 is associated with viraemia and multiple organ disease. Similar clinicopathological features have been previously seen in SARS and MERS. Clinically, the severity of SARS, MERS and COVID-19 has been associated with the presence of SARS-CoV, MERS-CoV or SARS-CoV2 viraemia in affected patients. In vitro work has looked at the pattern of viral entry and release from polarised epithelial cells infected by coronaviruses. This work has demonstrated a correlation between the severity of a coronavirus infection and the ability of the virus to reach and infect the basal surface of host cells. It has been postulated that this ability helps the virus invade the bloodstream of the host, resulting in a systemic infection with multiple organ involvement. Here we propose that basal surface release and entry of COVID-19 into and out of cells at epithelial-endothelial interface plays a key pathogenic role in severe COVID-19 disease.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
