Version 1
: Received: 20 May 2020 / Approved: 21 May 2020 / Online: 21 May 2020 (03:55:17 CEST)
How to cite:
Karim, M.R. The Emerging Potentials of Human Regulatory B Cells Mediated Therapies in Myasthenia Gravis. Preprints2020, 2020050334. https://doi.org/10.20944/preprints202005.0334.v1
Karim, M.R. The Emerging Potentials of Human Regulatory B Cells Mediated Therapies in Myasthenia Gravis. Preprints 2020, 2020050334. https://doi.org/10.20944/preprints202005.0334.v1
Karim, M.R. The Emerging Potentials of Human Regulatory B Cells Mediated Therapies in Myasthenia Gravis. Preprints2020, 2020050334. https://doi.org/10.20944/preprints202005.0334.v1
APA Style
Karim, M.R. (2020). The Emerging Potentials of Human Regulatory B Cells Mediated Therapies in Myasthenia Gravis. Preprints. https://doi.org/10.20944/preprints202005.0334.v1
Chicago/Turabian Style
Karim, M.R. 2020 "The Emerging Potentials of Human Regulatory B Cells Mediated Therapies in Myasthenia Gravis" Preprints. https://doi.org/10.20944/preprints202005.0334.v1
Abstract
Regulatory B cells (Bregs) with immunosuppressive function are critical in maintaining immune tolerance. In recent years, Bregs is an essential part of the study due to its therapeutic relevance and function in immune tolerance. The positive and negative regulatory role of human Bregs in immune tolerance is being discussed in several pathologies, including in autoimmune diseases, cancers, chronic infections, strokes in multiple reports. The negative regulatory roles of human Bregs are associated with lesser numbers and functional abnormalities in most of these studies, including myasthenia gravis (MG). In this review, the potential findings regarding human Bregs in MG, and Bregs mediated potential therapeutic strategies with its pros and cons have been discussed based on previous and current reports.
Keywords
Human Bregs; IL-10; IL-35; TGF- ß; myasthenia gravis; Bregs expansion
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
