Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Emerging Potentials of Human Regulatory B Cells Mediated Therapies in Myasthenia Gravis

Version 1 : Received: 20 May 2020 / Approved: 21 May 2020 / Online: 21 May 2020 (03:55:17 CEST)

How to cite: Karim, M.R. The Emerging Potentials of Human Regulatory B Cells Mediated Therapies in Myasthenia Gravis. Preprints 2020, 2020050334 (doi: 10.20944/preprints202005.0334.v1). Karim, M.R. The Emerging Potentials of Human Regulatory B Cells Mediated Therapies in Myasthenia Gravis. Preprints 2020, 2020050334 (doi: 10.20944/preprints202005.0334.v1).

Abstract

Regulatory B cells (Bregs) with immunosuppressive function are critical in maintaining immune tolerance. In recent years, Bregs is an essential part of the study due to its therapeutic relevance and function in immune tolerance. The positive and negative regulatory role of human Bregs in immune tolerance is being discussed in several pathologies, including in autoimmune diseases, cancers, chronic infections, strokes in multiple reports. The negative regulatory roles of human Bregs are associated with lesser numbers and functional abnormalities in most of these studies, including myasthenia gravis (MG). In this review, the potential findings regarding human Bregs in MG, and Bregs mediated potential therapeutic strategies with its pros and cons have been discussed based on previous and current reports.

Subject Areas

Human Bregs; IL-10; IL-35; TGF- ß; myasthenia gravis; Bregs expansion

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