Farshi, P., Kaya, E. C., Hashempour-Baltork, F., & Khosravi-Darani, K. The effect of plant metabolites on coronaviruses: A comprehensive review focusing on their IC50 values and molecular docking scores. Mini reviews in medicinal chemistry，2021, DOI: 10.2174/1389557521666210831152511
Farshi, P., Kaya, E. C., Hashempour-Baltork, F., & Khosravi-Darani, K. The effect of plant metabolites on coronaviruses: A comprehensive review focusing on their IC50 values and molecular docking scores. Mini reviews in medicinal chemistry，2021, DOI: 10.2174/1389557521666210831152511
Farshi, P., Kaya, E. C., Hashempour-Baltork, F., & Khosravi-Darani, K. The effect of plant metabolites on coronaviruses: A comprehensive review focusing on their IC50 values and molecular docking scores. Mini reviews in medicinal chemistry，2021, DOI: 10.2174/1389557521666210831152511
Farshi, P., Kaya, E. C., Hashempour-Baltork, F., & Khosravi-Darani, K. The effect of plant metabolites on coronaviruses: A comprehensive review focusing on their IC50 values and molecular docking scores. Mini reviews in medicinal chemistry，2021, DOI: 10.2174/1389557521666210831152511
Abstract
Coronaviruses such as SARS (severe acute respiratory syndrome), MERS (Middle East respiratory syndrome), and newly emerged SARS-CoV-2, also called 2019-nCoV and COVID 19, have caused worldwide outbreaks in different time periods. There are many studies about chemical and natural drugs to treat these coronaviruses by inhibiting their proteases or their protein receptors through binding to amino acid residues. Plants secondary and primary metabolites are considered as potential drugs to inhibit various types of coronaviruses. IC50 value (the concentration in which there is 50% loss in enzyme activity) and molecular docking score and binding energy are parameters to understand the metabolites ability to inhibit the specific virus. In this study we did review on more than 110 papers on plant metabolites effect on different coronaviruses. Secondary plant metabolites such as polyphenols (flavonoids, coumarins, stilbenes), alkaloids, terpenoids, organosulfur compounds saponins, saikosaponins, lectins, essential oils, nicotianamine and primary metabolites such as vitamins.
MEDICINE & PHARMACOLOGY, Pharmacology & Toxicology
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