This version is not peer-reviewed
On the Importance of Population-Based Serological Surveys of SARS-CoV-2 Without Overlooking Their Inherent Uncertainties
: Received: 7 May 2020 / Approved: 11 May 2020 / Online: 11 May 2020 (12:47:00 CEST)
A peer-reviewed article of this Preprint also exists.
Journal reference: Public Health in Practice 2020
This brief note aims to explain the scope in conducting large-scale serological surveys of SARS-CoV-2 to define the landscape of population immunity without overlooking the inherent uncertainty steaming from sampling design and diagnostic validity. The note completes with a succinct statistical appendix of simple methods for estimating prevalence from random population samples using imperfect diagnostic tests.
Serosurvey; seroepidemiology; seroprevalence; sampling; imperfect diagnostic test; sensitivity; specificity; Coronavirus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.