<strong>On the Importance of Population-Based Serological Surveys of SARS-CoV-2</strong> <strong>Without Overlooking Their Inherent Uncertainties</strong>

Evangelos Kritsotakis

doi:10.20944/preprints202005.0194.v1

Submitted:

07 May 2020

Posted:

11 May 2020

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Preprints on COVID-19 and SARS-CoV-2

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On the Importance of Population-Based Serological Surveys of SARS-CoV-2 Without Overlooking Their Inherent Uncertainties

Evangelos Kritsotakis^*

A peer-reviewed article of this preprint also exists.

Submitted:

07 May 2020

Posted:

11 May 2020

You are already at the latest version

Part of the Following Collection

Preprints on COVID-19 and SARS-CoV-2

Abstract

This brief note aims to explain the scope in conducting large-scale serological surveys of SARS-CoV-2 to define the landscape of population immunity without overlooking the inherent uncertainty steaming from sampling design and diagnostic validity. The note completes with a succinct statistical appendix of simple methods for estimating prevalence from random population samples using imperfect diagnostic tests.

Keywords:

Serosurvey

;

seroepidemiology

;

seroprevalence

;

sampling

;

imperfect diagnostic test

;

sensitivity

;

specificity

;

Coronavirus

Subject:

Computer Science and Mathematics - Probability and Statistics

Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.