Preprint Short Note Version 1 This version is not peer-reviewed

On the Importance of Population-Based Serological Surveys of SARS-CoV-2 Without Overlooking Their Inherent Uncertainties

Version 1 : Received: 7 May 2020 / Approved: 11 May 2020 / Online: 11 May 2020 (12:47:00 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: Public Health in Practice 2020
DOI: 10.1016/j.puhip.2020.100013

Abstract

This brief note aims to explain the scope in conducting large-scale serological surveys of SARS-CoV-2 to define the landscape of population immunity without overlooking the inherent uncertainty steaming from sampling design and diagnostic validity. The note completes with a succinct statistical appendix of simple methods for estimating prevalence from random population samples using imperfect diagnostic tests.

Subject Areas

Serosurvey; seroepidemiology; seroprevalence; sampling; imperfect diagnostic test; sensitivity; specificity; Coronavirus

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