Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Significance of Cancer Stem Cell Markers’ Gene Expression and Relevance for Survival Outcomes

Version 1 : Received: 3 May 2020 / Approved: 4 May 2020 / Online: 4 May 2020 (10:00:51 CEST)

A peer-reviewed article of this Preprint also exists.

Kevin Dzobo, Chelene Ganz, Nicholas Ekow Thomford, and Dimakatso Alice Senthebane.OMICS: A Journal of Integrative Biology. ahead of print Kevin Dzobo, Chelene Ganz, Nicholas Ekow Thomford, and Dimakatso Alice Senthebane.OMICS: A Journal of Integrative Biology. ahead of print


Solid tumors display complex biology and most therapies including chemotherapy cannot prevent therapy resistance and relapse. Most therapeutics target cancer cells, but recent data suggest the presence of cancer stem cells as cells with self-renewal and tumorigenic abilities. Cancer stem cell markers have been suggested to have prognostic value and can be targeted during cancer treatment and in resistant disease. CSCs have been postulated to play significant contextual roles in tumor initiation, progression, therapy resistance and metastasis. CSCs have thus been targeted by new generation cancer drugs. The transcriptional expression of several CSC markers in different cancers was evaluated by searching publicly available The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis (GEPIA) databases. We report here new findings on expression and prognostic significance of CSC markers in several cancers by examining the expression of CSCs markers in tumor tissues versus the adjacent normal tissues. We found that CSC markers were mostly highly expressed various tumors such as colon, lung, pancreatic and esophageal cancers. No CSC marker is expressed in the same pattern in all cancers and individual CSC marker expression was not linked to patient survival. This analysis calls for continued research on CSCs and clinical evaluation of the CSC markers in relation to prognosis of cancers in large population samples. Novel cancer drugs ought to target CSCs, cancer cells and tumor microenvironment variations.


tumor microenvironment; biomarkers; solid cancers; computational biology; cancer stem cells; anti-cancer stem cell therapy; chemotherapy


Biology and Life Sciences, Biochemistry and Molecular Biology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0

Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.