Working Paper Article Version 3 This version is not peer-reviewed

Application of Tensor Decomposition to Gene Expression of Infection of Mouse Hepatitis Virus can Identify Critical Human Genes and Efffective Drugs for SARS-CoV-2 Infection

Version 1 : Received: 23 April 2020 / Approved: 24 April 2020 / Online: 24 April 2020 (09:21:20 CEST)
Version 2 : Received: 16 June 2020 / Approved: 17 June 2020 / Online: 17 June 2020 (13:26:51 CEST)
Version 3 : Received: 6 December 2020 / Approved: 8 December 2020 / Online: 8 December 2020 (10:17:05 CET)

How to cite: Taguchi, Y.; Turki, T. Application of Tensor Decomposition to Gene Expression of Infection of Mouse Hepatitis Virus can Identify Critical Human Genes and Efffective Drugs for SARS-CoV-2 Infection. Preprints 2020, 2020040431 Taguchi, Y.; Turki, T. Application of Tensor Decomposition to Gene Expression of Infection of Mouse Hepatitis Virus can Identify Critical Human Genes and Efffective Drugs for SARS-CoV-2 Infection. Preprints 2020, 2020040431

Abstract

To better understand the genes with altered expression caused by infection with the novel coronavirus strain SARS-CoV-2 causing COVID-19 infectious disease, a tensor decomposition (TD)-based unsupervised feature extraction (FE) approach was applied to a gene expression profile dataset of the mouse liver and spleen with experimental infection of mouse hepatitis virus, which is regarded as a suitable model of human coronavirus infection. TD-based unsupervised FE selected 134 altered genes, which were enriched in protein-protein interactions with orf1ab, polyprotein, and 3C-like protease that are well known to play critical roles in coronavirus infection, suggesting that these 134 genes can represent the coronavirus infectious process. We then selected compounds targeting the expression of the 134 selected genes based on a public domain database. The identified drug compounds were mainly related to known antiviral drugs, several of which were also included in those previously screened with an in silico method to identify candidate drugs for treating COVID-19.

Subject Areas

COVID-19; SARS-CoV-2; in silico drug discovery; gene expression profile; tensor decomposition; feature extraction

Comments (1)

Comment 1
Received: 8 December 2020
Commenter: Y-H. Taguchi
Commenter's Conflict of Interests: Author
Comment: Revisions to address reviewers' comments. Modifications are heighlighted in red.
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