Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Neuroinvasive Potential of A Primary Respiratory Pathogen SARS-CoV2: Exploring the Underrecognized

Version 1 : Received: 20 April 2020 / Approved: 21 April 2020 / Online: 21 April 2020 (08:30:59 CEST)

How to cite: Lahiri, D.; Mondal, R.; Deb, S.; Bandopadhyay, D.; Shome, G.; Sarkar, S.; Biswas, S.C. Neuroinvasive Potential of A Primary Respiratory Pathogen SARS-CoV2: Exploring the Underrecognized. Preprints 2020, 2020040382 (doi: 10.20944/preprints202004.0382.v1). Lahiri, D.; Mondal, R.; Deb, S.; Bandopadhyay, D.; Shome, G.; Sarkar, S.; Biswas, S.C. Neuroinvasive Potential of A Primary Respiratory Pathogen SARS-CoV2: Exploring the Underrecognized. Preprints 2020, 2020040382 (doi: 10.20944/preprints202004.0382.v1).

Abstract

After the emergence of Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in the last two decades, the world is facing its new challenge in SARS-CoV-2 pandemic with unfathomable global responses. The characteristic clinical symptoms for Coronavirus (COVID-19) affected patients are high fever, dry-cough, dyspnoea, lethal pneumonia whereas some patients also show few additional neurological signs such as headache, nausea, vomiting. The accumulative evidences suggest that Coronavirus is not only confined within the respiratory tract and that may also invade in central nervous system (CNS), peripheral nervous system (PNS) inducing some fatal Neurological diseases. Here we analyse the phylogenetic perspective of SARS-CoV2 with other strains of β-Coronaviridae from a standpoint of neurological spectrum disorders. Based on the existing case reports, literature and open data-bases, we also analyse the differential distribution of neurological impairments in COVID-19 positive patients along with angiotensin-converting enzyme-2(ACE2) expression dynamics in neuronal and non-neuronal tissue of central and peripheral nervous system. Besides, we discuss the need for modulations in clinical approach from a neurological point of view, as a measure towards reducing disease transmission, morbidity and mortality in SARS-CoV2 positive patients.

Subject Areas

COVID-19; ACE2; SARS-CoV; neurological disorders; phylogenetic perspective; coronavirus; CNS; PNS

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