Article
Version 1
Preserved in Portico This version is not peer-reviewed
Modelling and Simulation of the Hydrodynamics and Mixing Profiles in the Human Proximal Colon Using Discrete Multiphysics
Version 1
: Received: 9 April 2020 / Approved: 12 April 2020 / Online: 12 April 2020 (15:57:17 CEST)
A peer-reviewed article of this Preprint also exists.
Abstract
The proximal part of the colon offers opportunities to prolong the absorption window following oral administration of a drug. In this work, we used computer simulations to understand how the hydrodynamics in the proximal colon might affect the release from dosage forms designed to target the colon. For this purpose, we developed and compared three different models: a completely-filled colon, a partially-filled colon and a partially-filled colon with a gaseous phase present (gas-liquid model).The highest velocities of the liquid were found in the completely-filled model, which also shows the best mixing profile, defined by the distribution of tracking particles over time. No significant differences with regard to the mixing and velocity profiles were found between the partially-filled model and the gas-liquid model. The fastest transit time of an undissolved tablet was found in the completely-filled model. The velocities of the liquid in the gas-liquid model are slightly higher along the colon than in the partially-filled model. The filling level has an impact on the exsisting shear forces and shear rates, which are decisive factors in the development of new drugs and formulations.
Keywords
mathematical modelling; peristalsis; smoothed particle hydrodynamics (SPH); fluid dynamics; large intestine; colonl proximal colon; fluid-structure interactions; drug delivery
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
