Preprint Brief Report Version 1 This version is not peer-reviewed

Comparative Analysis Based on the Spike Glycoproteins of SARS-CoV2 Isolated from COVID 19 Patients of Different Countries

Version 1 : Received: 5 April 2020 / Approved: 9 April 2020 / Online: 9 April 2020 (13:15:21 CEST)

How to cite: Mangar, P.; Pradhan, S.; Rai, S.; Lepcha, K.; Ranjan, V.K.; Rai, A. Comparative Analysis Based on the Spike Glycoproteins of SARS-CoV2 Isolated from COVID 19 Patients of Different Countries. Preprints 2020, 2020040154 (doi: 10.20944/preprints202004.0154.v1). Mangar, P.; Pradhan, S.; Rai, S.; Lepcha, K.; Ranjan, V.K.; Rai, A. Comparative Analysis Based on the Spike Glycoproteins of SARS-CoV2 Isolated from COVID 19 Patients of Different Countries. Preprints 2020, 2020040154 (doi: 10.20944/preprints202004.0154.v1).

Abstract

SARS-CoV2 popularly known as (COVID-19) has presently received worldwide attention. It has been considered a pandemic by the World Health Organisation. Owing to its high transmittance factor the virus has brought about many deaths and spread to all the major countries of the world. Scientists and Researchers worldwide are giving their full efforts to develop a vaccine. In our present study, we have included the comparative analysis of the different spike glycoprotein sequences of the patients suffering from COVID-19 from different countries where this pandemic has occurred. Spike glycoproteins are the structural proteins that bring about the binding of the SARS-CoV-2 viral molecule to the ACE2 receptor of the host following which infection occurs. Through this data, we have shown the different point mutations in the spike glycoproteins that occurred over time in different countries as the disease progressed.

Subject Areas

SARS-CoV2; spike glycoprotein; mutation

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