Preprint Article Version 1 This version is not peer-reviewed

Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve

Version 1 : Received: 2 April 2020 / Approved: 7 April 2020 / Online: 7 April 2020 (13:33:02 CEST)

How to cite: Mohammed, A.M.; Ariane, M.; Alexiadis, A. Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve. Preprints 2020, 2020040107 (doi: 10.20944/preprints202004.0107.v1). Mohammed, A.M.; Ariane, M.; Alexiadis, A. Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve. Preprints 2020, 2020040107 (doi: 10.20944/preprints202004.0107.v1).

Abstract

This study proposes a 3D particle-base (discrete) multiphysics approach for modelling calcification in the aortic valve. Different stages of calcification (from mild to severe) were simulated, and their effect on the cardiac output assessed. The cardiac flow rate decreases with the level of calcification. In particular, there is a critical level of calcification below which the flow rate decreases dramatically. Mechanical stress on the membrane is also calculated. The results show that, as calcification progresses, spots of high mechanical stress appear. Firstly, they concentrate in the regions connecting two leaflets; when severe calcification is reached, then they extend to the area at the basis of the valve.

Subject Areas

Discrete Multiphysics Modelling; Smoothed Particle Hydrodynamics; Lattice Spring Model; Particle-base method; Aortic Valve; Calcification; Stenosis

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