Preprint Brief Report Version 1 This version is not peer-reviewed

The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues

Version 1 : Received: 3 April 2020 / Approved: 7 April 2020 / Online: 7 April 2020 (02:27:40 CEST)

A peer-reviewed article of this Preprint also exists.

Darbani, B. The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues. Int. J. Environ. Res. Public Health 2020, 17, 3433. Darbani, B. The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues. Int. J. Environ. Res. Public Health 2020, 17, 3433.

Journal reference: Int. J. Environ. Res. Public Health 2020, 17
DOI: 10.3390/ijerph17103433

Abstract

Combating viral disease outbreaks has doubtlessly been one of the major public health challenges for the 21st century. Here, the host entry machinery required for COVID-19 (SARS-CoV-2) infection was examined for the gene expression profiles and polymorphism. The four human population groups of Europeans, Africans, Asians, and Americans had specific and also a shared pool of variants for the X-linked locus of ACE2 receptor. Several specific and common ACE2 variants were of the utmost importance to the viral entry and infection. In the absence of gender bias for the gene expression profiles, the hemizygous rare variants of ACE2 describe the observed higher mortality rate in males. Finally, a personalized medicine strategy is conceived for isolating high-risk individuals in epidemic circumstances.

Subject Areas

COVID-19; gender; host entry machinery; polymorphism

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