Preprint Hypothesis Version 1 This version is not peer-reviewed

How to Further Reduce the Risk of Serious COVID-19 Infections: Exploiting the Fragile Viral Envelope and the Self-Cleaning Mechanisms of Our Respiratory System

Version 1 : Received: 24 March 2020 / Approved: 29 March 2020 / Online: 29 March 2020 (03:12:09 CEST)

How to cite: Vogel, V. How to Further Reduce the Risk of Serious COVID-19 Infections: Exploiting the Fragile Viral Envelope and the Self-Cleaning Mechanisms of Our Respiratory System. Preprints 2020, 2020030415 (doi: 10.20944/preprints202003.0415.v1). Vogel, V. How to Further Reduce the Risk of Serious COVID-19 Infections: Exploiting the Fragile Viral Envelope and the Self-Cleaning Mechanisms of Our Respiratory System. Preprints 2020, 2020030415 (doi: 10.20944/preprints202003.0415.v1).

Abstract

Social distancing, washing hands and good hygiene are essential and currently the most potent methods available to curb down the unprecedented speed by which the new coronavirus is spreading across the globe. Even under lockdown, which is necessary to significantly reduce the number of people that get infected by an ill person, are there additional measures that each of us can embrace to even further reduce the risk of infection and the severity of the COVID-19 disease? Given the lack of licensed drugs that target SARS-CoV-2 specifically, we have to look into additional non-specific defense mechanisms that animals and humans evolved to protect themselves from pathogen invasions. The goal of this article is to describe how various of our non-specific defense mechanisms work, which actually precede the inflammatory response, and to discuss whether we can exploit the unique features of the coronavirus envelope and the self-cleaning machinery of the human respiratory tract to strengthen our self-defense. The challenge is to actively interfere with supportive measures during the short time window between getting exposed and before an inflammatory response gets initiated.

Subject Areas

coronavirus; self-defense mechanisms of the human body

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