Working Paper Case Report Version 1 This version is not peer-reviewed

Novel Coronavirus Infection and Acute Kidney Injury in Two Renal Transplant Recipients: Case Report

Version 1 : Received: 11 March 2020 / Approved: 12 March 2020 / Online: 12 March 2020 (03:02:03 CET)

How to cite: Li, Q.; Cheng, Q.; Zhao, Z.; Zeng, L.; Zhu, L.; Guo, W.; Li, C.; Wang, J.; Li, S.; Shen, N.; Ge, Q. Novel Coronavirus Infection and Acute Kidney Injury in Two Renal Transplant Recipients: Case Report. Preprints 2020, 2020030190 Li, Q.; Cheng, Q.; Zhao, Z.; Zeng, L.; Zhu, L.; Guo, W.; Li, C.; Wang, J.; Li, S.; Shen, N.; Ge, Q. Novel Coronavirus Infection and Acute Kidney Injury in Two Renal Transplant Recipients: Case Report. Preprints 2020, 2020030190

Abstract

Novel coronavirus infection is a recent infective agent that causes severe potentially fatal pneumonia. The clinical presentation includes asymptomatic infection, severe pneumonia, and acute respiratory failure. Data pertaining to the clinical presentation of solid organ transplant recipients are scarce. Two cases of novel coronavirus infection in two recipients of renal transplant with variable clinical presentations and outcomes are reported. The first patient presented with progressive respiratory symptoms, acute renal failure, and passed away, whereas the second one, although presented with respiratory tract symptoms and hypoxemia remained stable and exhibited an excellent clinical recovery despite recent reception of thymoglobulin induction. This paper reports rare cases of novel coronavirus infection in renal transplant recipients. For an enhanced insight of the novel coronavirus infection and acute kidney injury on the clinical presentation, severity, and outcome in solid organ transplant recipients, further investigations are required.

Subject Areas

novel coronavirus infection; renal transplant; acute kidney injury

Comments (1)

Comment 1
Received: 2 April 2020
Commenter: Carles Alonso-Tarrés
The commenter has declared there is no conflict of interests.
Comment: Dear Dr. Li and coworkers, Thank you for your excellent report. It is accepted that COVID-19 recovered patients have to remain isolated during 14 days after illness resolution. Some authors (1) have described that the median duration of viral shedding in recovered COVID-19 patients is 20.0 days (IQR 17•0–24•0) from illness onset, with 8 days being the shortest period and 37 the longest. This study was made in the general population. Little is known about persistence of viral shedding in immunosupressed individuals, but their immunity state might alter the viral shedding period. Have you studied the persistence of positive SARS-CoV-2 PCR in the patient who recovered? Although it would be only one patient, this information could be usefull Reference: (1) Zhou F1, Yu T2, Du R et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28; 395(10229): 1054-1062. doi: 10.1016/S0140-6736(20)30566-3. Epub 2020 Mar 11.
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