Thalidomide Combined with Low-dose Glucocorticoid in the Treatment of COVID-19 Pneumonia

Chengshui Chen; Feng Qi; Keqing Shi; Yuping Li; Ji Li; Yongping Chen; Jingye Pan; Tieli Zhou; Xiangyang Lin; Jinsan Zhang; Yongde Luo; Xiaokun Li; Jinglin Xia

Working Paper Case Report Version 1 This version is not peer-reviewed

Version 1 : Received: 26 February 2020 / Approved: 26 February 2020 / Online: 26 February 2020 (12:31:47 CET)

A novel coronavirus strain (severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first appeared in December 2019 and can cause acute respiratory distress syndrome and death. However, there are only limited therapy choices and no vaccine for SARS-CoV-2 is currently available. Here we report about a case of a SARS-CoV-2 caused pneumonia successfully treated with thalidomide. Thalidomide is an immunomodulatory and anti-inflammatory agent and was combined with a low-dose glucocorticoid. We suggest, that the effects of thalidomide might be related to regulating immunity, inhibiting the inflammatory cytokine surge, alleviating anxiety to reduce oxygen consumption, relieving vomit and lung exudation.

Coronavirus; SARS-CoV-2; COVID-19; Thalidomide; pneumonia

Medicine and Pharmacology, Immunology and Allergy

Comment 1

Received: 28 February 2020
Commenter: Taylor Zhang
The commenter has declared there is no conflict of interests.

Comment: Thalidomide is an old medicine, but this case report shows it's effects of inhibiting the inflammatory cytokine surge. It deserves a futher study.

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Thalidomide Combined with Low-dose Glucocorticoid in the Treatment of COVID-19 Pneumonia

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