Working Paper Case Report Version 1 This version is not peer-reviewed

Thalidomide Combined with Low-dose Glucocorticoid in the Treatment of COVID-19 Pneumonia

Version 1 : Received: 26 February 2020 / Approved: 26 February 2020 / Online: 26 February 2020 (12:31:47 CET)

How to cite: Chen, C.; Qi, F.; Shi, K.; Li, Y.; Li, J.; Chen, Y.; Pan, J.; Zhou, T.; Lin, X.; Zhang, J.; Luo, Y.; Li, X.; Xia, J. Thalidomide Combined with Low-dose Glucocorticoid in the Treatment of COVID-19 Pneumonia. Preprints 2020, 2020020395 Chen, C.; Qi, F.; Shi, K.; Li, Y.; Li, J.; Chen, Y.; Pan, J.; Zhou, T.; Lin, X.; Zhang, J.; Luo, Y.; Li, X.; Xia, J. Thalidomide Combined with Low-dose Glucocorticoid in the Treatment of COVID-19 Pneumonia. Preprints 2020, 2020020395

Abstract

A novel coronavirus strain (severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first appeared in December 2019 and can cause acute respiratory distress syndrome and death. However, there are only limited therapy choices and no vaccine for SARS-CoV-2 is currently available. Here we report about a case of a SARS-CoV-2 caused pneumonia successfully treated with thalidomide. Thalidomide is an immunomodulatory and anti-inflammatory agent and was combined with a low-dose glucocorticoid. We suggest, that the effects of thalidomide might be related to regulating immunity, inhibiting the inflammatory cytokine surge, alleviating anxiety to reduce oxygen consumption, relieving vomit and lung exudation.

Subject Areas

Coronavirus; SARS-CoV-2; COVID-19; Thalidomide; pneumonia

Comments (1)

Comment 1
Received: 28 February 2020
Commenter: Taylor Zhang
The commenter has declared there is no conflict of interests.
Comment: Thalidomide is an old medicine, but this case report shows it's effects of inhibiting the inflammatory cytokine surge. It deserves a futher study.
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