Version 1
: Received: 17 February 2020 / Approved: 18 February 2020 / Online: 18 February 2020 (11:15:32 CET)
How to cite:
Darweesh, M.; Hady, A.; salman, H. Characterization of Essential Fatty Acid Semicarbazide (EFASC) from Linum usitatissium as a Safe and Effective Adjuvant. Preprints2020, 2020020267
Darweesh, M.; Hady, A.; salman, H. Characterization of Essential Fatty Acid Semicarbazide (EFASC) from Linum usitatissium as a Safe and Effective Adjuvant. Preprints 2020, 2020020267
Darweesh, M.; Hady, A.; salman, H. Characterization of Essential Fatty Acid Semicarbazide (EFASC) from Linum usitatissium as a Safe and Effective Adjuvant. Preprints2020, 2020020267
APA Style
Darweesh, M., Hady, A., & salman, H. (2020). Characterization of Essential Fatty Acid Semicarbazide (EFASC) from <em>Linum usitatissium</em> as a Safe and Effective Adjuvant. Preprints. https://doi.org/
Chicago/Turabian Style
Darweesh, M., Ahmad Hady and Hayat salman. 2020 "Characterization of Essential Fatty Acid Semicarbazide (EFASC) from <em>Linum usitatissium</em> as a Safe and Effective Adjuvant" Preprints. https://doi.org/
Abstract
Bacterial infections are world-wide problem and resistant bacteria is increasing globally that lead to treatments failure. Thus, it is important to find new techniques that are effective for the treatment antibiotic-resistant microorganisms. Green medicine used for the medication of different bacterial infection. Therefore , the study aimed to evaluate the immunomodulatory activity of essential fatty acid semi carbazide (EFASC) compounds extracted from flaxseed to eradicate resistance pathogens . Crud extracts of Linum usitatissimum was extracted by hexane for extraction of EFASC. The results of LD50 appear that a live suspension of E.coliwas 0.49×107 ,while HK E.coli was 108 , 125 mg /ml were the optimum dose in stimulate immune response of EFASC which gave maximum dose of total WBC , Neutrophil and Monocyte count. The immunomodulatory activity appear that E.coli + EFASC released moderate levels of IL-4 . HK E.coli release higher IL-4 lead to increase the hypersensitivity and hyper responses of immune system. HK + EFASC immunogen revealed moderate increased in IL-12 mean level 0.99 pg /ml, HK bacteria recorded 1.49 pg/ml, while the mean of EFASC revealed no significant different compare with control. An effective protection was observed in immunized groups with HK E.coli and EFASC challenged with 100 of LD50 of a live E.coli.
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
