Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis

Version 1 : Received: 18 January 2020 / Approved: 19 January 2020 / Online: 19 January 2020 (05:12:19 CET)

A peer-reviewed article of this Preprint also exists.

Goetschalckx, E.; Mekahli, D.; Levtchenko, E.; Allegaert, K. Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis. Int. J. Environ. Res. Public Health 2020, 17, 2144. Goetschalckx, E.; Mekahli, D.; Levtchenko, E.; Allegaert, K. Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis. Int. J. Environ. Res. Public Health 2020, 17, 2144.

Journal reference: Int. J. Environ. Res. Public Health 2020, 17, 2144
DOI: 10.3390/ijerph17062144

Abstract

Different cohort studies documented a lower glomerular filtration rate (GFR) in former extremely low birth weight (ELBW, <1000 g) neonates throughout childhood when compared to term controls. The current aim is to pool these studies to describe the GFR pattern over the pediatric age range. To do so, we conducted a systematic review on studies reporting on GFR measurements in former ELBW cases while GFR data of healthy age-matched controls included in these studies were co-collected. Based on 248 hits, 6 case-control and 3 cohort studies were identified, with 444 GFR measurements in 380 former ELBW cases (median age 5.3-20.7 years). The majority were small (17-78 cases) single center studies, with heterogeneity in GFR measurement (inulin, Cystatin C or creatinine estimated GFR formulae) tools. Despite this, the median GFR (ml/kg/1.73m2) within case-control studies was consistently lower (-13, range -8 to -25%) in cases, so that a relevant minority (15-30%) has a eGFR<90 mgl/kg/1.73m2). Consequently, this pooled analysis describes a consistent pattern of reduced eGFR in former ELBW cases throughout childhood. Research should focus on perinatal risk factors for impaired GFR and long-term outcome, but is hampered by single center cohorts, study size, and heterogeneity of GFR assessment tools.

Subject Areas

glomerular filtration rate; Brenner hypothesis; extreme low birth weight infants; renal outcome

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