Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

A Hypothesis of Symbiosis between Humans and Poliovirus as a Critical Evolutionary Step in Human Speciation

Version 1 : Received: 3 December 2019 / Approved: 4 December 2019 / Online: 4 December 2019 (11:09:42 CET)

How to cite: Amin, A.S. A Hypothesis of Symbiosis between Humans and Poliovirus as a Critical Evolutionary Step in Human Speciation. Preprints 2019, 2019120046 (doi: 10.20944/preprints201912.0046.v1). Amin, A.S. A Hypothesis of Symbiosis between Humans and Poliovirus as a Critical Evolutionary Step in Human Speciation. Preprints 2019, 2019120046 (doi: 10.20944/preprints201912.0046.v1).

Abstract

No single evolutionary event has been identified as the cause for the final emergence of our species. I propose that a mutation on CD155 receptor gene occurred to establish a symbiosis with poliovirus, which exerted its beneficial impact via RNA dependent non-genetic transgenerational inheritance, which caused a qualitative enhancement of cognitive functions. I posit that this mutation occurred in what we call, Anatomically Modern Humans, our immediate ancestor species and that the disruption of this symbiosis causes autism spectrum disorder. Positive selection of CD155 to the extent of becoming a species defining characteristic, the chronology of autism spectrum disorder prevalence increase and continued increase, the multigenerational nature of RNA inheritance, the universal infection of humans by poliovirus and a very low associated mortality rate, and several other factors support this hypothesis. Specific genetic, epidemiological and sperm miRNA content studies are suggested to test this hypothesis.

Subject Areas

symbiosis; speciation; humans; polio; CD155; PVR; evolution; ASD; autism

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