Version 1
: Received: 8 November 2019 / Approved: 10 November 2019 / Online: 10 November 2019 (09:29:13 CET)
How to cite:
Takenaka, S.; Sukenaga, N.; Imasaka, M.; Ohmuraya, M.; Matsuki, Y.; Maeda, L.; Takao, Y.; Hirose, M. Association between Neuropathic Pain Characteristics and DNA Methylation of TRPA1 in Human Peripheral Blood. Preprints2019, 2019110101. https://doi.org/10.20944/preprints201911.0101.v1
Takenaka, S.; Sukenaga, N.; Imasaka, M.; Ohmuraya, M.; Matsuki, Y.; Maeda, L.; Takao, Y.; Hirose, M. Association between Neuropathic Pain Characteristics and DNA Methylation of TRPA1 in Human Peripheral Blood. Preprints 2019, 2019110101. https://doi.org/10.20944/preprints201911.0101.v1
Takenaka, S.; Sukenaga, N.; Imasaka, M.; Ohmuraya, M.; Matsuki, Y.; Maeda, L.; Takao, Y.; Hirose, M. Association between Neuropathic Pain Characteristics and DNA Methylation of TRPA1 in Human Peripheral Blood. Preprints2019, 2019110101. https://doi.org/10.20944/preprints201911.0101.v1
APA Style
Takenaka, S., Sukenaga, N., Imasaka, M., Ohmuraya, M., Matsuki, Y., Maeda, L., Takao, Y., & Hirose, M. (2019). Association between Neuropathic Pain Characteristics and DNA Methylation of <em>TRPA1</em> in Human Peripheral Blood. Preprints. https://doi.org/10.20944/preprints201911.0101.v1
Chicago/Turabian Style
Takenaka, S., Yumiko Takao and Munetaka Hirose. 2019 "Association between Neuropathic Pain Characteristics and DNA Methylation of <em>TRPA1</em> in Human Peripheral Blood" Preprints. https://doi.org/10.20944/preprints201911.0101.v1
Abstract
Background: Elucidation of epigenetic mechanisms correlating with neuropathic pain in humans is crucial for the prevention and treatment of this treatment-resistant pain state. In the present study, associations between neuropathic pain characteristics and DNA methylation of the transient receptor potential ankyrin 1(TRPA1) gene were evaluated in chronic pain patients and preoperative patients. Methods: Pain and psychological states were prospectively assessed in patients who suffered chronic pain or were scheduled for thoracic surgery. Neuropathic characteristics were assessed using the Douleur Neuropathique 4 (DN4) questionnaire. DNA methylation levels of the CpG island in the TRPA1 gene were examined using whole blood. Results: Forty-eight adult patients were enrolled in this study. Increases in DNA methylation rates at CpG -51 showed positive correlations with increases in the DN4 score both in preoperative and chronic pain patients. Combined methylation rates at CpG -51 also significantly increased together with increase in DN4 scores. Conclusions: Neuropathic pain characteristics are likely associated with methylation rates at the promoter region of the TRPA1 gene in human peripheral blood.
Medicine and Pharmacology, Anesthesiology and Pain Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
